Inhibitory Effect of Alpha-Mangostin to Dengue Virus Replication and Cytokines Expression in Human Peripheral Blood Mononuclear Cells

ABSTRACT: Massive pro-inflammatory cytokines production has been correlated with the pathogenesis of severe dengue disease. The active compound of mangosteen fruit pericarps, α-mangostin, has been commonly used as traditional medicine and dietary supplement. We examined the effect of α-mangostin aga...

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Detalles Bibliográficos
Autores principales: Sugiyanto, Zaenal, Yohan, Benediktus, Hadisaputro, Soeharyo, Dharmana, Edi, Suharti, Catharina, Winarto, Djamiatun, Kis, Rahmi, Fifin L., Sasmono, R. Tedjo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2019
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814697/
https://www.ncbi.nlm.nih.gov/pubmed/31538308
http://dx.doi.org/10.1007/s13659-019-00218-z
Descripción
Sumario:ABSTRACT: Massive pro-inflammatory cytokines production has been correlated with the pathogenesis of severe dengue disease. The active compound of mangosteen fruit pericarps, α-mangostin, has been commonly used as traditional medicine and dietary supplement. We examined the effect of α-mangostin against dengue virus (DENV) infection in human peripheral blood mononuclear cells (PBMC) by the measurement of virus titer and TNF-α and IFN-γ cytokines concentration post infection. Increasing concentration of α-mangostin inhibited virus replication and reduced inflammatory cytokines expression at 24- and 48-h post infection. Our results support the potential use of α-mangostin as anti-antiviral and anti-inflammatory therapies in the treatment of dengue. GRAPHIC ABSTRACT: [Image: see text]

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