Tankyrase inhibition preserves osteoarthritic cartilage by coordinating cartilage matrix anabolism via effects on SOX9 PARylation

Osteoarthritis (OA) is a prevalent degenerative disease, which involves progressive and irreversible destruction of cartilage matrix. Despite efforts to reconstruct cartilage matrix in osteoarthritic joints, it has been a difficult task as adult cartilage exhibits marginal repair capacity. Here we r...

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Detalles Bibliográficos
Autores principales: Kim, Sukyeong, Han, Sangbin, Kim, Yeongjae, Kim, Hyeon-Seop, Gu, Young-Ran, Kang, Donghyun, Cho, Yongsik, Kim, Hyeonkyeong, Lee, Jeeyeon, Seo, Yeyoung, Chang, Moon Jong, Chang, Chong Bum, Kang, Seung-Baik, Kim, Jin-Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814715/
https://www.ncbi.nlm.nih.gov/pubmed/31653858
http://dx.doi.org/10.1038/s41467-019-12910-2

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