Cargando…

Single-cell transcriptomic atlas of the human retina identifies cell types associated with age-related macular degeneration

Genome-wide association studies (GWAS) have identified genetic variants associated with age-related macular degeneration (AMD), one of the leading causes of blindness in the elderly. However, it has been challenging to identify the cell types associated with AMD given the genetic complexity of the d...

Descripción completa

Detalles Bibliográficos
Autores principales:	Menon, Madhvi, Mohammadi, Shahin, Davila-Velderrain, Jose, Goods, Brittany A., Cadwell, Tanina D., Xing, Yu, Stemmer-Rachamimov, Anat, Shalek, Alex K., Love, John Christopher, Kellis, Manolis, Hafler, Brian P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814749/ https://www.ncbi.nlm.nih.gov/pubmed/31653841 http://dx.doi.org/10.1038/s41467-019-12780-8

Ejemplares similares

A multiresolution framework to characterize single-cell state landscapes
por: Mohammadi, Shahin, et al.
Publicado: (2020)

NEBULA is a fast negative binomial mixed model for differential or co-expression analysis of large-scale multi-subject single-cell data
por: He, Liang, et al.
Publicado: (2021)

Integrative construction of regulatory region networks in 127 human reference epigenomes by matrix factorization
por: Liu, Dianbo, et al.
Publicado: (2019)

Contextual influences in the peripheral retina of patients with macular degeneration
por: Contemori, Giulio, et al.
Publicado: (2019)

Single-cell analysis reveals inflammatory interactions driving macular degeneration
por: Kuchroo, Manik, et al.
Publicado: (2023)

Guidelines for the management of neovascular age-related macular degeneration by the European Society of Retina Specialists (EURETINA)
por: Schmidt-Erfurth, Ursula, et al.
Publicado: (2014)

Innate immune biology in age-related macular degeneration
por: Ascunce, Karina, et al.
Publicado: (2023)

Correction to: An update on the CNS manifestations of neurofibromatosis type 2
por: Coy, Shannon, et al.
Publicado: (2019)

An update on the CNS manifestations of neurofibromatosis type 2
por: Coy, Shannon, et al.
Publicado: (2019)

Neutrophils homing into the retina trigger pathology in early age-related macular degeneration
por: Ghosh, Sayan, et al.
Publicado: (2019)

Cellular senescence in the aging retina and developments of senotherapies for age-related macular degeneration
por: Lee, Keng Siang, et al.
Publicado: (2021)

Adenosine Receptors Expression in Human Retina and Choroid with Age-related Macular Degeneration
por: Goebel, Collin P., et al.
Publicado: (2023)

Decreased Vision and Junctional Scotoma from Pituicytoma
por: Huynh, Nancy, et al.
Publicado: (2012)

BACE-1 inhibition facilitates the transition from homeostatic microglia to DAM-1
por: Singh, Neeraj, et al.
Publicado: (2022)

A Novel Source of Methylglyoxal and Glyoxal in Retina: Implications for Age-Related Macular Degeneration
por: Yoon, Kee Dong, et al.
Publicado: (2012)

Prevalence of and risk factors for age-related macular degeneration in Nepal: the Bhaktapur Retina Study
por: Thapa, Raba, et al.
Publicado: (2017)

Oxidative stress in the light-exposed retina and its implication in age-related macular degeneration
por: Ozawa, Yoko
Publicado: (2020)

Oxidative Stress-Induced Cellular Senescence in Aging Retina and Age-Related Macular Degeneration
por: Terao, Ryo, et al.
Publicado: (2022)

P38 MAPK Signaling in the Retina: Effects of Aging and Age-Related Macular Degeneration
por: Muraleva, Natalia A., et al.
Publicado: (2023)

Platinum Nanozymes Counteract Photoreceptor Degeneration and Retina Inflammation in a Light-Damage Model of Age-Related Macular Degeneration
por: Cupini, Sara, et al.
Publicado: (2023)

Early detection of age related macular degeneration: current status
por: Schwartz, Roy, et al.
Publicado: (2015)

Cholesterol-enriched diet causes age-related macular degeneration-like pathology in rabbit retina
por: Dasari, Bhanu, et al.
Publicado: (2011)

The Effect of Ranibizumab on Normal Neurosensory Retina in the Eyes of Patients with Exudative Age Related Macular Degeneration
por: Makri, Olga E., et al.
Publicado: (2017)

Differential Expression of Kinin Receptors in Human Wet and Dry Age-Related Macular Degeneration Retinae
por: Othman, Rahmeh, et al.
Publicado: (2020)

Inner blood-retina barrier involvement in dry age-related macular degeneration (AMD) pathology
por: Hudson, Natalie, et al.
Publicado: (2020)

Watching synchronous mitochondrial respiration in the retina and its instability in a mouse model of macular degeneration
por: Kaynezhad, Pardis, et al.
Publicado: (2021)

Iron Accumulation and Lipid Peroxidation in the Aging Retina: Implication of Ferroptosis in Age-Related Macular Degeneration
por: Zhao, Tantai, et al.
Publicado: (2021)

Functional Correlates of Outer Retina Remodeling in Intermediate Age-Related Macular Degeneration Using Microperimetry
por: Fragiotta, Serena, et al.
Publicado: (2022)

Single-cell transcriptomics of staged oocytes and somatic cells reveal novel regulators of follicle activation
por: Chen, Yu-Ying, et al.
Publicado: (2022)

Spontaneous rupture of an arachnoid cyst in an adult: illustrative case
por: Leavitt, Lydia A., et al.
Publicado: (2023)

Functional differences between PD-1(+) and PD-1(-) CD4(+) effector T cells in healthy donors and patients with glioblastoma multiforme
por: Goods, Brittany A., et al.
Publicado: (2017)

Macular Hole following Intravitreal Bevacizumab Injection in Choroidal Neovascularization Caused by Age-Related Macular Degeneration
por: Moisseiev, Elad, et al.
Publicado: (2010)

Population awareness of diabetic eye disease and age related macular degeneration in Nepal: the Bhaktapur Retina Study
por: Thapa, Raba, et al.
Publicado: (2015)

Thermal Stimulation of the Retina Reduces Bruch's Membrane Thickness in Age Related Macular Degeneration Mouse Models
por: Tode, Jan, et al.
Publicado: (2018)

The distribution of toxic metals in the human retina and optic nerve head: Implications for age-related macular degeneration
por: Pamphlett, Roger, et al.
Publicado: (2020)

Disruptions of Autophagy in the Rat Retina with Age During the Development of Age-Related-Macular-Degeneration-like Retinopathy
por: Kozhevnikova, Oyuna S., et al.
Publicado: (2019)

Diagnostic Markers and Molecular Dysregulation Mechanisms in the Retinal Pigmented Epithelium and Retina of Age-Related Macular Degeneration
por: Li, Yao, et al.
Publicado: (2022)

Effects of smoking on the retina of patients with dry age-related macular degeneration by optical coherence tomography angiography
por: Yang, Weizhou, et al.
Publicado: (2022)

Antioxidative Role of Heterophagy, Autophagy, and Mitophagy in the Retina and Their Association with the Age-Related Macular Degeneration (AMD) Etiopathogenesis
por: Nita, Małgorzata, et al.
Publicado: (2023)

A case of antisynthetase syndrome with thrombotic thrombocytopenic purpura
por: Goreshnik, Ashley, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_evk997ftpssr52plpm0dj7r9dk