YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression

Hypoxia occurs naturally at high-altitudes and pathologically in hypoxic solid tumors. Here, we report that genes involved in various human cancers evolved rapidly in Tibetans and six Tibetan domestic mammals compared to reciprocal lowlanders. Furthermore, m(6)A modified mRNA binding protein YTHDF1,...

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Detalles Bibliográficos
Autores principales: Shi, Yulin, Fan, Songqing, Wu, Mengge, Zuo, Zhixiang, Li, Xingyang, Jiang, Liping, Shen, Qiushuo, Xu, Peifang, Zeng, Lin, Zhou, Yongchun, Huang, Yunchao, Yang, Zuozhang, Zhou, Jumin, Gao, Jing, Zhou, Hu, Xu, Shuhua, Ji, Hongbin, Shi, Peng, Wu, Dong-Dong, Yang, Cuiping, Chen, Yongbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814821/
https://www.ncbi.nlm.nih.gov/pubmed/31653849
http://dx.doi.org/10.1038/s41467-019-12801-6

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