Cargando…

The striatal-enriched protein Rhes is a critical modulator of cocaine-induced molecular and behavioral responses

Previous evidence pointed out a role for the striatal-enriched protein Rhes in modulating dopaminergic transmission. Based on the knowledge that cocaine induces both addiction and motor stimulation, through its ability to enhance dopaminergic signaling in the corpus striatum, we have now explored th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Napolitano, Francesco, De Rosa, Arianna, Russo, Rosita, Di Maio, Anna, Garofalo, Martina, Federici, Mauro, Migliarini, Sara, Ledonne, Ada, Rizzo, Francesca Romana, Avallone, Luigi, Nuzzo, Tommaso, Biagini, Tommaso, Pasqualetti, Massimo, Mercuri, Nicola Biagio, Mazza, Tommaso, Chambery, Angela, Usiello, Alessandro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814836/ https://www.ncbi.nlm.nih.gov/pubmed/31653935 http://dx.doi.org/10.1038/s41598-019-51839-w

Ejemplares similares

Rhes influences striatal cAMP/PKA-dependent signaling and synaptic plasticity in a gender-sensitive fashion
por: Ghiglieri, Veronica, et al.
Publicado: (2015)

Involvement of the Protein Ras Homolog Enriched in the Striatum, Rhes, in Dopaminergic Neurons’ Degeneration: Link to Parkinson’s Disease
por: Serra, Marcello, et al.
Publicado: (2021)

Decreased Rhes mRNA levels in the brain of patients with Parkinson’s disease and MPTP-treated macaques
por: Napolitano, Francesco, et al.
Publicado: (2017)

Rhes Counteracts Dopamine Neuron Degeneration and Neuroinflammation Depending on Gender and Age
por: Costa, Giulia, et al.
Publicado: (2018)

Rhes, a striatal–enriched small G–protein, mediates mTOR signaling and L–DOPA–induced dyskinesia
por: Subramaniam, Srinivasa, et al.
Publicado: (2011)

Rhes, a striatal-enriched protein, promotes mitophagy via Nix
por: Sharma, Manish, et al.
Publicado: (2019)

Striatal Induction and Spread of the Huntington’s Disease Protein: A Novel Rhes Route
por: Subramaniam, Srinivasa
Publicado: (2022)

Lack of Rhes Increases MDMA-Induced Neuroinflammation and Dopamine Neuron Degeneration: Role of Gender and Age
por: Costa, Giulia, et al.
Publicado: (2019)

Perturbation of Serotonin Homeostasis during Adulthood Affects Serotonergic Neuronal Circuitry
por: Pratelli, Marta, et al.
Publicado: (2017)

Dysfunctional dopaminergic neurotransmission in asocial BTBR mice
por: Squillace, M, et al.
Publicado: (2014)

Rhes depletion promotes striatal accumulation and aggregation of mutant huntingtin in a presymptomatic HD mouse model
por: Pan, Yongcheng, et al.
Publicado: (2023)

MicroRNA-101 inhibits the expression of Rhes, a striatal-enriched small G-protein, at the post-transcriptional level in vitro
por: Mizuno, Hideya, et al.
Publicado: (2018)

Nusinersen mitigates neuroinflammation in severe spinal muscular atrophy patients
por: Nuzzo, Tommaso, et al.
Publicado: (2023)

D-aspartate oxidase gene duplication induces social recognition memory deficit in mice and intellectual disabilities in humans
por: Lombardo, Barbara, et al.
Publicado: (2022)

mGluR1-Dependent Long Term Depression in Rodent Midbrain Dopamine Neurons Is Regulated by Neuregulin 1/ErbB Signaling
por: Ledonne, Ada, et al.
Publicado: (2018)

Long-Term Depression of Striatal DA Release Induced by mGluRs via Sustained Hyperactivity of Local Cholinergic Interneurons
por: Mercuri, Nicola B., et al.
Publicado: (2021)

A2A Adenosine Receptor Antagonism Enhances Synaptic and Motor Effects of Cocaine via CB1 Cannabinoid Receptor Activation
por: Tozzi, Alessandro, et al.
Publicado: (2012)

Exploration of sex differences in Rhes effects in dopamine mediated behaviors
por: Quintero, Gabriel C, et al.
Publicado: (2011)

The Emerging Role of Altered d-Aspartate Metabolism in Schizophrenia: New Insights From Preclinical Models and Human Studies
por: Errico, Francesco, et al.
Publicado: (2018)

Rapamycin, by Inhibiting mTORC1 Signaling, Prevents the Loss of Striatal Bidirectional Synaptic Plasticity in a Rat Model of L-DOPA-Induced Dyskinesia
por: Calabrese, Valeria, et al.
Publicado: (2020)

Small G Proteins Dexras1 and RHES and Their Role in Pathophysiological Processes
por: Thapliyal, Ashish, et al.
Publicado: (2014)

Global Rhes knockout in the Q175 Huntington’s disease mouse model
por: Heikkinen, Taneli, et al.
Publicado: (2021)

Abnormal RasGRP1 Expression in the Post-Mortem Brain and Blood Serum of Schizophrenia Patients
por: De Rosa, Arianna, et al.
Publicado: (2022)

Emerging Roles of Protease-Activated Receptors (PARs) in the Modulation of Synaptic Transmission and Plasticity
por: Price, Rachel, et al.
Publicado: (2021)

Machine Learning algorithm unveils glutamatergic alterations in the post-mortem schizophrenia brain
por: De Rosa, Arianna, et al.
Publicado: (2022)

Electrophysiological Effects of Trace Amines on Mesencephalic Dopaminergic Neurons
por: Ledonne, Ada, et al.
Publicado: (2011)

RhythmicDB: A Database of Predicted Multi-Frequency Rhythmic Transcripts
por: Castellana, Stefano, et al.
Publicado: (2022)

Orbitofrontal-striatal potentiation underlies cocaine-induced hyperactivity
por: Bariselli, Sebastiano, et al.
Publicado: (2020)

Rhes protein transits from neuron to neuron and facilitates mutant huntingtin spreading in the brain
por: Ramírez-Jarquín, Uri Nimrod, et al.
Publicado: (2022)

Analysis of mRNA and Protein Levels of CAP2, DLG1 and ADAM10 Genes in Post-Mortem Brain of Schizophrenia, Parkinson’s and Alzheimer’s Disease Patients
por: Di Maio, Anna, et al.
Publicado: (2022)

Connecting the dots: A practical evaluation of web-tools for describing protein dynamics as networks
por: Petrizzelli, Francesco, et al.
Publicado: (2022)

Early-Onset Diabetes as Risk Factor for Pancreatic Cancer: miRNA Expression Profiling in Plasma Uncovers a Role for miR-20b-5p, miR-29a, and miR-18a-5p in Diabetes of Recent Diagnosis
por: Tavano, Francesca, et al.
Publicado: (2020)

Convergent abnormalities in striatal gene networks in human cocaine use disorder and mouse cocaine administration models
por: Mews, Philipp, et al.
Publicado: (2023)

Pathophysiological Features of Nigral Dopaminergic Neurons in Animal Models of Parkinson’s Disease
por: Guatteo, Ezia, et al.
Publicado: (2022)

High-confidence assessment of functional impact of human mitochondrial non-synonymous genome variations by APOGEE
por: Castellana, Stefano, et al.
Publicado: (2017)

Attenuation of Rhes Activity Significantly Delays the Appearance of Behavioral Symptoms in a Mouse Model of Huntington's Disease
por: Baiamonte, Brandon A., et al.
Publicado: (2013)

Rhes travels from cell to cell and transports Huntington disease protein via TNT-like protrusion
por: Sharma, Manish, et al.
Publicado: (2019)

Striatal microRNA controls cocaine intake through CREB signaling
por: Hollander, Jonathan A., et al.
Publicado: (2010)

Differential Regulation of the Period Genes in Striatal Regions following Cocaine Exposure
por: Falcon, Edgardo, et al.
Publicado: (2013)

Pyntacle: a parallel computing-enabled framework for large-scale network biology analysis
por: Parca, Luca, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_m4m5jm6kjmdosc4n1lhtce27e6