Protection from noise-induced cochlear synaptopathy by virally mediated overexpression of NT3

Noise exposures causing only transient threshold shifts can destroy auditory-nerve synapses without damaging hair cells. Here, we asked whether virally mediated neurotrophin3 (NT3) overexpression can repair this damage. CBA/CaJ mice at 6 wks were injected unilaterally with adeno-associated virus (AA...

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Detalles Bibliográficos
Autores principales: Hashimoto, Ken, Hickman, Tyler T., Suzuki, Jun, Ji, Lingchao, Kohrman, David C., Corfas, Gabriel, Liberman, M. Charles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814859/
https://www.ncbi.nlm.nih.gov/pubmed/31653916
http://dx.doi.org/10.1038/s41598-019-51724-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814859/
https://www.ncbi.nlm.nih.gov/pubmed/31653916
http://dx.doi.org/10.1038/s41598-019-51724-6

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