Cargando…
Can Low SHBG Serum Concentration Be A Good Early Marker Of Male Hypogonadism In Metabolic Syndrome?
INTRODUCTION: In men suffering from metabolic syndrome, accompanying insulin resistance may result in a lowering of sex hormone–binding globulin (SHBG) plasma levels and cause changes in their androgenic status. AIM: The objective of the research was to assess selected androgens and SHBG plasma leve...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814954/ https://www.ncbi.nlm.nih.gov/pubmed/31695461 http://dx.doi.org/10.2147/DMSO.S218545 |
_version_ | 1783463096698798080 |
---|---|
author | Jarecki, Piotr Herman, Waldemar A Pawliczak, Elżbieta Lacka, Katarzyna |
author_facet | Jarecki, Piotr Herman, Waldemar A Pawliczak, Elżbieta Lacka, Katarzyna |
author_sort | Jarecki, Piotr |
collection | PubMed |
description | INTRODUCTION: In men suffering from metabolic syndrome, accompanying insulin resistance may result in a lowering of sex hormone–binding globulin (SHBG) plasma levels and cause changes in their androgenic status. AIM: The objective of the research was to assess selected androgens and SHBG plasma levels in males meeting diagnostic criteria for MS compared to healthy males. PATIENTS AND METHODS: The group consisted of 65 men aged between 40 and 70 years old fitting IDF metabolic syndrome criteria and 84 controls. Dehydroepiandrosterone (DHEA) and its sulphate (DHEA–S), total and free testosterone and SHBG serum levels were evaluated. Calculated free and bioavailable testosterone were estimated using an algorithm proposed by the International Society for the Study of the Aging Male. RESULTS: Men diagnosed with MS showed a statistically significant decrease in plasma levels of DHEA in comparison to healthy ones: 11.579 (8.39–15.56) vs 14.014 (9.611–17.125) ng/mL; p = 0.0350, SHBG: 47.46 (35.78–62.83) vs 71.965 (54.45–91.56) nM/L; p<0.0001 and total testosterone: 5.2 (3.8–6.5) vs 6.3 (5.4–8.25) ng/mL; p = 0.0001 (values presented as a median with Q1–Q3). CONCLUSION: The results suggest that SHBG is a good early marker for metabolic dysregulation in MS, considering its strength of association and significance is comparable to, or better than, those of MS criteria. |
format | Online Article Text |
id | pubmed-6814954 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-68149542019-11-06 Can Low SHBG Serum Concentration Be A Good Early Marker Of Male Hypogonadism In Metabolic Syndrome? Jarecki, Piotr Herman, Waldemar A Pawliczak, Elżbieta Lacka, Katarzyna Diabetes Metab Syndr Obes Original Research INTRODUCTION: In men suffering from metabolic syndrome, accompanying insulin resistance may result in a lowering of sex hormone–binding globulin (SHBG) plasma levels and cause changes in their androgenic status. AIM: The objective of the research was to assess selected androgens and SHBG plasma levels in males meeting diagnostic criteria for MS compared to healthy males. PATIENTS AND METHODS: The group consisted of 65 men aged between 40 and 70 years old fitting IDF metabolic syndrome criteria and 84 controls. Dehydroepiandrosterone (DHEA) and its sulphate (DHEA–S), total and free testosterone and SHBG serum levels were evaluated. Calculated free and bioavailable testosterone were estimated using an algorithm proposed by the International Society for the Study of the Aging Male. RESULTS: Men diagnosed with MS showed a statistically significant decrease in plasma levels of DHEA in comparison to healthy ones: 11.579 (8.39–15.56) vs 14.014 (9.611–17.125) ng/mL; p = 0.0350, SHBG: 47.46 (35.78–62.83) vs 71.965 (54.45–91.56) nM/L; p<0.0001 and total testosterone: 5.2 (3.8–6.5) vs 6.3 (5.4–8.25) ng/mL; p = 0.0001 (values presented as a median with Q1–Q3). CONCLUSION: The results suggest that SHBG is a good early marker for metabolic dysregulation in MS, considering its strength of association and significance is comparable to, or better than, those of MS criteria. Dove 2019-10-21 /pmc/articles/PMC6814954/ /pubmed/31695461 http://dx.doi.org/10.2147/DMSO.S218545 Text en © 2019 Jarecki et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Jarecki, Piotr Herman, Waldemar A Pawliczak, Elżbieta Lacka, Katarzyna Can Low SHBG Serum Concentration Be A Good Early Marker Of Male Hypogonadism In Metabolic Syndrome? |
title | Can Low SHBG Serum Concentration Be A Good Early Marker Of Male Hypogonadism In Metabolic Syndrome? |
title_full | Can Low SHBG Serum Concentration Be A Good Early Marker Of Male Hypogonadism In Metabolic Syndrome? |
title_fullStr | Can Low SHBG Serum Concentration Be A Good Early Marker Of Male Hypogonadism In Metabolic Syndrome? |
title_full_unstemmed | Can Low SHBG Serum Concentration Be A Good Early Marker Of Male Hypogonadism In Metabolic Syndrome? |
title_short | Can Low SHBG Serum Concentration Be A Good Early Marker Of Male Hypogonadism In Metabolic Syndrome? |
title_sort | can low shbg serum concentration be a good early marker of male hypogonadism in metabolic syndrome? |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814954/ https://www.ncbi.nlm.nih.gov/pubmed/31695461 http://dx.doi.org/10.2147/DMSO.S218545 |
work_keys_str_mv | AT jareckipiotr canlowshbgserumconcentrationbeagoodearlymarkerofmalehypogonadisminmetabolicsyndrome AT hermanwaldemara canlowshbgserumconcentrationbeagoodearlymarkerofmalehypogonadisminmetabolicsyndrome AT pawliczakelzbieta canlowshbgserumconcentrationbeagoodearlymarkerofmalehypogonadisminmetabolicsyndrome AT lackakatarzyna canlowshbgserumconcentrationbeagoodearlymarkerofmalehypogonadisminmetabolicsyndrome |