HOPS: a quantitative score reveals pervasive horizontal pleiotropy in human genetic variation is driven by extreme polygenicity of human traits and diseases

Horizontal pleiotropy, where one variant has independent effects on multiple traits, is important for our understanding of the genetic architecture of human phenotypes. We develop a method to quantify horizontal pleiotropy using genome-wide association summary statistics and apply it to 372 heritabl...

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Detalles Bibliográficos
Autores principales: Jordan, Daniel M., Verbanck, Marie, Do, Ron
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815001/
https://www.ncbi.nlm.nih.gov/pubmed/31653226
http://dx.doi.org/10.1186/s13059-019-1844-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815001/
https://www.ncbi.nlm.nih.gov/pubmed/31653226
http://dx.doi.org/10.1186/s13059-019-1844-7

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