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Dasatinib regulates LPS-induced microglial and astrocytic neuroinflammatory responses by inhibiting AKT/STAT3 signaling

BACKGROUND: The FDA-approved small-molecule drug dasatinib is currently used as a treatment for chronic myeloid leukemia (CML). However, the effects of dasatinib on microglial and/or astrocytic neuroinflammatory responses and its mechanism of action have not been studied in detail. METHODS: BV2 micr...

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Detalles Bibliográficos
Autores principales:	Ryu, Ka-Young, Lee, Hyun-ju, Woo, Hanwoong, Kang, Ri-Jin, Han, Kyung-Min, Park, HyunHee, Lee, Sang Min, Lee, Ju-Young, Jeong, Yoo Joo, Nam, Hyun-Wook, Nam, Youngpyo, Hoe, Hyang-Sook
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815018/ https://www.ncbi.nlm.nih.gov/pubmed/31655606 http://dx.doi.org/10.1186/s12974-019-1561-x

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