Improving detection of JC virus by ultrafiltration of cerebrospinal fluid before polymerase chain reaction for the diagnosis of progressive multifocal leukoencephalopathy

BACKGROUND: Progressive multifocal leukoencephalopathy (PML) is a demyelinating disorder caused by JC virus (JCV). Although detecting JCV DNA in the cerebrospinal fluid (CSF) by real-time polymerase chain reaction (PCR) is useful, diagnosis is difficult when JCV concentrations are low. We therefore...

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Detalles Bibliográficos
Autores principales: Nakamichi, Kazuo, Kawamoto, Michi, Ishii, Junko, Saijo, Masayuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815041/
https://www.ncbi.nlm.nih.gov/pubmed/31653203
http://dx.doi.org/10.1186/s12883-019-1476-2

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