Cargando…

Lipid-targeting pleckstrin homology domain turns its autoinhibitory face toward the TEC kinases

The pleckstrin homology (PH) domain is well known for its phospholipid targeting function. The PH-TEC homology (PHTH) domain within the TEC family of tyrosine kinases is also a crucial component of the autoinhibitory apparatus. The autoinhibitory surface on the PHTH domain has been previously define...

Descripción completa

Detalles Bibliográficos
Autores principales:	Amatya, Neha, Wales, Thomas E., Kwon, Annie, Yeung, Wayland, Joseph, Raji E., Fulton, D. Bruce, Kannan, Natarajan, Engen, John R., Andreotti, Amy H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2019
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815127/ https://www.ncbi.nlm.nih.gov/pubmed/31591208 http://dx.doi.org/10.1073/pnas.1907566116

Ejemplares similares

Dynamic Allostery Mediated by a Conserved Tryptophan in the Tec Family Kinases
por: Chopra, Nikita, et al.
Publicado: (2016)

Differential impact of BTK active site inhibitors on the conformational state of full-length BTK
por: Joseph, Raji E, et al.
Publicado: (2020)

Conformational switches that control the TEC kinase – PLCγ signaling axis
por: Lowe, Jacques, et al.
Publicado: (2022)

Membrane and Protein Interactions of the Pleckstrin Homology Domain Superfamily
por: Lenoir, Marc, et al.
Publicado: (2015)

Systematic simulation of the interactions of pleckstrin homology domains with membranes
por: Le Huray, Kyle I. P., et al.
Publicado: (2022)

Structural and Functional Characterization of the Kindlin-1 Pleckstrin Homology Domain
por: Yates, Luke A., et al.
Publicado: (2012)

The pleckstrin-homology domain of dynamin is dispensable for membrane constriction and fission
por: Dar, Srishti, et al.
Publicado: (2017)

Bacterial Pleckstrin Homology Domains: A Prokaryotic Origin for the PH Domain
por: Xu, Qingping, et al.
Publicado: (2010)

Structural basis of wedging the Golgi membrane by FAPP pleckstrin homology domains
por: Lenoir, Marc, et al.
Publicado: (2010)

The oncogenic mutation in the pleckstrin homology domain of AKT1 in endometrial carcinomas
por: Shoji, K, et al.
Publicado: (2009)

Structure and lipid-binding properties of the kindlin-3 pleckstrin homology domain
por: Ni, Tao, et al.
Publicado: (2017)

Biophysical and Computational Studies of Membrane Penetration by the GRP1 Pleckstrin Homology Domain
por: Lumb, Craig N., et al.
Publicado: (2011)

Alternate pleckstrin homology domain orientations regulate dynamin-catalyzed membrane fission
por: Mehrotra, Niharika, et al.
Publicado: (2014)

FaceTec ties the knot with dating app firm
Publicado: (2020)

Role of the pleckstrin homology domain of PLCγ1 in its interaction with the insulin receptor
por: Kwon, Yong-Kook, et al.
Publicado: (2003)

IQSEC2‐related encephalopathy in males due to missense variants in the pleckstrin homology domain
por: Shoubridge, Cheryl, et al.
Publicado: (2022)

Autoinhibition of the formin Cappuccino in the absence of canonical autoinhibitory domains
por: Bor, Batbileg, et al.
Publicado: (2012)

Autoinhibitory Feedback Control over Photodynamic Action
por: Yurt, Mediha Nur Zafer, et al.
Publicado: (2019)

Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14
por: Depetris, Rafael S, et al.
Publicado: (2009)

Specialized structural and functional roles of residues selectively conserved in subfamilies of the pleckstrin homology domain family
por: Naveenkumar, Nagarajan, et al.
Publicado: (2019)

Pleckstrin homology domain of phospholipase D2 is a negative regulator of focal adhesion kinase
por: Kim, Mi Kyoung, et al.
Publicado: (2021)

Flexible pivoting of dynamin pleckstrin homology domain catalyzes fission: insights into molecular degrees of freedom
por: Baratam, Krishnakanth, et al.
Publicado: (2021)

Evolution of Functional Diversity in the Holozoan Tyrosine Kinome
por: Yeung, Wayland, et al.
Publicado: (2021)

Hadp1, a newly identified pleckstrin homology domain protein, is required for cardiac contractility in zebrafish
por: Wythe, Joshua D., et al.
Publicado: (2011)

Interactions of Pleckstrin Homology Domains with Membranes: Adding Back the Bilayer via High-Throughput Molecular Dynamics
por: Yamamoto, Eiji, et al.
Publicado: (2016)

TEC Installation
por: CERN. Geneva. Audiovisual Unit
Publicado: (1989)

Novel Role for Pleckstrin Homology‐Like Domain Family A, Member 3 in the Regulation of Pathological Cardiac Hypertrophy
por: Liu, Jia, et al.
Publicado: (2019)

Mechanistic analysis of a novel membrane-interacting variable loop in the pleckstrin-homology domain critical for dynamin function
por: Khurana, Himani, et al.
Publicado: (2023)

Alignment-free estimation of sequence conservation for identifying functional sites using protein sequence embeddings
por: Yeung, Wayland, et al.
Publicado: (2023)

An autoinhibitory clamp of actin assembly constrains and directs synaptic endocytosis
por: Del Signore, Steven J, et al.
Publicado: (2021)

A Novel Pleckstrin Homology Domain-containing Protein Enhances Insulin-stimulated Akt Phosphorylation and GLUT4 Translocation in Adipocytes
por: Zhou, Qiong L., et al.
Publicado: (2010)

Rac Regulates Its Effector Phospholipase Cγ(2) through Interaction with a Split Pleckstrin Homology Domain
por: Walliser, Claudia, et al.
Publicado: (2008)

Role of Phosphatidylinositol 3′ Kinase and a Downstream Pleckstrin Homology Domain–Containing Protein in Controlling Chemotaxis inDictyostelium
por: Funamoto, Satoru, et al.
Publicado: (2001)

The fission yeast pleckstrin homology domain protein Spo7 is essential for initiation of forespore membrane assembly and spore morphogenesis
por: Nakamura-Kubo, Michiko, et al.
Publicado: (2011)

Crystal Structure of the Pleckstrin Homology Domain from the Ceramide Transfer Protein: Implications for Conformational Change upon Ligand Binding
por: Prashek, Jennifer, et al.
Publicado: (2013)

Novel Inhibitors Induce Large Conformational Changes of GAB1 Pleckstrin Homology Domain and Kill Breast Cancer Cells
por: Chen, Lu, et al.
Publicado: (2015)

Insights into the inhibitory mechanism of triazole-based small molecules on phosphatidylinositol-4,5-bisphosphate binding pleckstrin homology domain
por: Gorai, Sukhamoy, et al.
Publicado: (2015)

Structural and biochemical characterization of the pleckstrin homology domain of the RhoGEF P-Rex2 and its regulation by PIP(3)
por: Cash, Jennifer N., et al.
Publicado: (2018)

The expression patterns and prognostic significance of pleckstrin homology-like domain family A (PHLDA) in lung cancer and malignant mesothelioma
por: Baldavira, Camila M., et al.
Publicado: (2021)

Deletion of Src Homology 3 Domain Results in Constitutive Activation of Tec Protein‐Tyrosine Kinase
por: Yamashita, Yoshihiro, et al.
Publicado: (1996)

Cannot write session to /tmp/vufind_sessions/sess_9bbfs1fmeru1dksllbja4o2v5u