Late-onset Niemann–Pick disease type C overlapping with frontotemporal dementia syndromes: a case report

The diagnosis of adult-onset Niemann–Pick disease type C (NPC) could be difficult because its primary symptoms [dementia and vertical supranuclear gaze palsy (VSGP)] are mainly seen in neurodegenerative dementias and progressive supranuclear palsy (PSP). Our patient with dementia and asymmetric park...

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Autores principales: Balázs, Nóra, Milanovich, Dániel, Hornyák, Csilla, Bereczki, Dániel, Kovács, Tibor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2019
Materias:
Neurology and Preclinical Neurological Studies - Short communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815276/
https://www.ncbi.nlm.nih.gov/pubmed/31506735
http://dx.doi.org/10.1007/s00702-019-02058-0
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author Balázs, Nóra
Milanovich, Dániel
Hornyák, Csilla
Bereczki, Dániel
Kovács, Tibor
author_facet Balázs, Nóra
Milanovich, Dániel
Hornyák, Csilla
Bereczki, Dániel
Kovács, Tibor
author_sort Balázs, Nóra
collection PubMed
description The diagnosis of adult-onset Niemann–Pick disease type C (NPC) could be difficult because its primary symptoms [dementia and vertical supranuclear gaze palsy (VSGP)] are mainly seen in neurodegenerative dementias and progressive supranuclear palsy (PSP). Our patient with dementia and asymmetric parkinsonism resembled corticobasal syndrome and after the appearance of VSGP, the criteria of PSP were fulfilled too. Cerebellar symptoms appeared late during the course of the disease, leading to the diagnosis of NPC at the age of 59 years.
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spelling pubmed-68152762019-11-06 Late-onset Niemann–Pick disease type C overlapping with frontotemporal dementia syndromes: a case report Balázs, Nóra Milanovich, Dániel Hornyák, Csilla Bereczki, Dániel Kovács, Tibor J Neural Transm (Vienna) Neurology and Preclinical Neurological Studies - Short communication The diagnosis of adult-onset Niemann–Pick disease type C (NPC) could be difficult because its primary symptoms [dementia and vertical supranuclear gaze palsy (VSGP)] are mainly seen in neurodegenerative dementias and progressive supranuclear palsy (PSP). Our patient with dementia and asymmetric parkinsonism resembled corticobasal syndrome and after the appearance of VSGP, the criteria of PSP were fulfilled too. Cerebellar symptoms appeared late during the course of the disease, leading to the diagnosis of NPC at the age of 59 years. Springer Vienna 2019-09-10 2019 /pmc/articles/PMC6815276/ /pubmed/31506735 http://dx.doi.org/10.1007/s00702-019-02058-0 Text en © The Author(s) 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Neurology and Preclinical Neurological Studies - Short communication
Balázs, Nóra
Milanovich, Dániel
Hornyák, Csilla
Bereczki, Dániel
Kovács, Tibor
Late-onset Niemann–Pick disease type C overlapping with frontotemporal dementia syndromes: a case report
title Late-onset Niemann–Pick disease type C overlapping with frontotemporal dementia syndromes: a case report
title_full Late-onset Niemann–Pick disease type C overlapping with frontotemporal dementia syndromes: a case report
title_fullStr Late-onset Niemann–Pick disease type C overlapping with frontotemporal dementia syndromes: a case report
title_full_unstemmed Late-onset Niemann–Pick disease type C overlapping with frontotemporal dementia syndromes: a case report
title_short Late-onset Niemann–Pick disease type C overlapping with frontotemporal dementia syndromes: a case report
title_sort late-onset niemann–pick disease type c overlapping with frontotemporal dementia syndromes: a case report
topic Neurology and Preclinical Neurological Studies - Short communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815276/
https://www.ncbi.nlm.nih.gov/pubmed/31506735
http://dx.doi.org/10.1007/s00702-019-02058-0
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