Cargando…

Human Plasma Levels of VEGF-A, VEGF-C, VEGF-D, their Soluble Receptor - VEGFR-2 and Applicability of these Parameters as Tumor Markers in the Diagnostics of Breast Cancer

VEGF family members are important factors in promoting angio- and lymphangiogenesis. The aim of this study was to investigate concentrations, diagnostic utility and power of VEGF-A, VEGF-C, VEGF-D and VEGFR-2 in comparison to CA15–3 in breast cancer (BC) patients. The study included 120 BC patients...

Descripción completa

Detalles Bibliográficos
Autores principales: Zajkowska, Monika, Lubowicka, Emilia, Fiedorowicz, Wojciech, Szmitkowski, Maciej, Jamiołkowski, Jacek, Ławicki, Sławomir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815280/
https://www.ncbi.nlm.nih.gov/pubmed/30387014
http://dx.doi.org/10.1007/s12253-018-0527-0
_version_ 1783463149802881024
author Zajkowska, Monika
Lubowicka, Emilia
Fiedorowicz, Wojciech
Szmitkowski, Maciej
Jamiołkowski, Jacek
Ławicki, Sławomir
author_facet Zajkowska, Monika
Lubowicka, Emilia
Fiedorowicz, Wojciech
Szmitkowski, Maciej
Jamiołkowski, Jacek
Ławicki, Sławomir
author_sort Zajkowska, Monika
collection PubMed
description VEGF family members are important factors in promoting angio- and lymphangiogenesis. The aim of this study was to investigate concentrations, diagnostic utility and power of VEGF-A, VEGF-C, VEGF-D and VEGFR-2 in comparison to CA15–3 in breast cancer (BC) patients. The study included 120 BC patients and 60 control patients (28 with benign breast tumors and 32 healthy women). Plasma levels of tested parameters were determined by ELISA, CA15–3 by CMIA. Concentrations of all parameters showed statistical significance when compared BC patients to controls. VEGF-D showed the highest SE (82.50%) in total BC group. Highest SP and PPV in total BC group showed VEGF-A(76.67%;84.78%,respectively), but lower than CA15–3. Highest NPV showed VEGF-C(52.33%), but it was lower than CA15–3. VEGF-C was also the best parameter which had statistically significant AUC in total cancer group (0.7672), but also stages I(0.7684) and II(0.7772). In the total group of BC almost all tested parameters showed statistically significant AUC, but a maximum range was obtained for the combination of VEGF-C + CA15–3(0.8476). The combined analysis of tested parameters and CA15–3 resulted in increase in SE and AUC values, which provides hope for developing a new panel of biomarkers that may be used in the diagnosis of BC in the future.
format Online
Article
Text
id pubmed-6815280
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Springer Netherlands
record_format MEDLINE/PubMed
spelling pubmed-68152802019-11-06 Human Plasma Levels of VEGF-A, VEGF-C, VEGF-D, their Soluble Receptor - VEGFR-2 and Applicability of these Parameters as Tumor Markers in the Diagnostics of Breast Cancer Zajkowska, Monika Lubowicka, Emilia Fiedorowicz, Wojciech Szmitkowski, Maciej Jamiołkowski, Jacek Ławicki, Sławomir Pathol Oncol Res Original Article VEGF family members are important factors in promoting angio- and lymphangiogenesis. The aim of this study was to investigate concentrations, diagnostic utility and power of VEGF-A, VEGF-C, VEGF-D and VEGFR-2 in comparison to CA15–3 in breast cancer (BC) patients. The study included 120 BC patients and 60 control patients (28 with benign breast tumors and 32 healthy women). Plasma levels of tested parameters were determined by ELISA, CA15–3 by CMIA. Concentrations of all parameters showed statistical significance when compared BC patients to controls. VEGF-D showed the highest SE (82.50%) in total BC group. Highest SP and PPV in total BC group showed VEGF-A(76.67%;84.78%,respectively), but lower than CA15–3. Highest NPV showed VEGF-C(52.33%), but it was lower than CA15–3. VEGF-C was also the best parameter which had statistically significant AUC in total cancer group (0.7672), but also stages I(0.7684) and II(0.7772). In the total group of BC almost all tested parameters showed statistically significant AUC, but a maximum range was obtained for the combination of VEGF-C + CA15–3(0.8476). The combined analysis of tested parameters and CA15–3 resulted in increase in SE and AUC values, which provides hope for developing a new panel of biomarkers that may be used in the diagnosis of BC in the future. Springer Netherlands 2018-11-01 2019 /pmc/articles/PMC6815280/ /pubmed/30387014 http://dx.doi.org/10.1007/s12253-018-0527-0 Text en © The Author(s) 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Zajkowska, Monika
Lubowicka, Emilia
Fiedorowicz, Wojciech
Szmitkowski, Maciej
Jamiołkowski, Jacek
Ławicki, Sławomir
Human Plasma Levels of VEGF-A, VEGF-C, VEGF-D, their Soluble Receptor - VEGFR-2 and Applicability of these Parameters as Tumor Markers in the Diagnostics of Breast Cancer
title Human Plasma Levels of VEGF-A, VEGF-C, VEGF-D, their Soluble Receptor - VEGFR-2 and Applicability of these Parameters as Tumor Markers in the Diagnostics of Breast Cancer
title_full Human Plasma Levels of VEGF-A, VEGF-C, VEGF-D, their Soluble Receptor - VEGFR-2 and Applicability of these Parameters as Tumor Markers in the Diagnostics of Breast Cancer
title_fullStr Human Plasma Levels of VEGF-A, VEGF-C, VEGF-D, their Soluble Receptor - VEGFR-2 and Applicability of these Parameters as Tumor Markers in the Diagnostics of Breast Cancer
title_full_unstemmed Human Plasma Levels of VEGF-A, VEGF-C, VEGF-D, their Soluble Receptor - VEGFR-2 and Applicability of these Parameters as Tumor Markers in the Diagnostics of Breast Cancer
title_short Human Plasma Levels of VEGF-A, VEGF-C, VEGF-D, their Soluble Receptor - VEGFR-2 and Applicability of these Parameters as Tumor Markers in the Diagnostics of Breast Cancer
title_sort human plasma levels of vegf-a, vegf-c, vegf-d, their soluble receptor - vegfr-2 and applicability of these parameters as tumor markers in the diagnostics of breast cancer
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815280/
https://www.ncbi.nlm.nih.gov/pubmed/30387014
http://dx.doi.org/10.1007/s12253-018-0527-0
work_keys_str_mv AT zajkowskamonika humanplasmalevelsofvegfavegfcvegfdtheirsolublereceptorvegfr2andapplicabilityoftheseparametersastumormarkersinthediagnosticsofbreastcancer
AT lubowickaemilia humanplasmalevelsofvegfavegfcvegfdtheirsolublereceptorvegfr2andapplicabilityoftheseparametersastumormarkersinthediagnosticsofbreastcancer
AT fiedorowiczwojciech humanplasmalevelsofvegfavegfcvegfdtheirsolublereceptorvegfr2andapplicabilityoftheseparametersastumormarkersinthediagnosticsofbreastcancer
AT szmitkowskimaciej humanplasmalevelsofvegfavegfcvegfdtheirsolublereceptorvegfr2andapplicabilityoftheseparametersastumormarkersinthediagnosticsofbreastcancer
AT jamiołkowskijacek humanplasmalevelsofvegfavegfcvegfdtheirsolublereceptorvegfr2andapplicabilityoftheseparametersastumormarkersinthediagnosticsofbreastcancer
AT ławickisławomir humanplasmalevelsofvegfavegfcvegfdtheirsolublereceptorvegfr2andapplicabilityoftheseparametersastumormarkersinthediagnosticsofbreastcancer