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Effect of induced dNTP pool imbalance on HIV-1 reverse transcription in macrophages

BACKGROUND: Terminally differentiated/nondividing macrophages, a key target cell type of HIV-1, harbor extremely low dNTP concentrations established by a host dNTP triphosphohydrolase, SAM domain and HD domain containing protein 1 (SAMHD1). We tested whether the induction of dNTP pool imbalance can...

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Detalles Bibliográficos
Autores principales:	Shepard, Caitlin, Xu, Joella, Holler, Jessica, Kim, Dong-Hyun, Mansky, Louis M., Schinazi, Raymond F., Kim, Baek
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815395/ https://www.ncbi.nlm.nih.gov/pubmed/31655617 http://dx.doi.org/10.1186/s12977-019-0491-0

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