Cargando…

Hypertension and Its Impact on Stroke Recovery: From a Vascular to a Parenchymal Overview

Hypertension is the first modifiable vascular risk factor accounting for 10.4 million deaths worldwide; it is strongly and independently associated with the risk of stroke and is related to worse prognosis. In addition, hypertension seems to be a key player in the implementation of vascular cognitiv...

Descripción completa

Detalles Bibliográficos
Autores principales: Maïer, Benjamin, Kubis, Nathalie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815533/
https://www.ncbi.nlm.nih.gov/pubmed/31737062
http://dx.doi.org/10.1155/2019/6843895
_version_ 1783463203127164928
author Maïer, Benjamin
Kubis, Nathalie
author_facet Maïer, Benjamin
Kubis, Nathalie
author_sort Maïer, Benjamin
collection PubMed
description Hypertension is the first modifiable vascular risk factor accounting for 10.4 million deaths worldwide; it is strongly and independently associated with the risk of stroke and is related to worse prognosis. In addition, hypertension seems to be a key player in the implementation of vascular cognitive impairment. Long-term hypertension, complicated or not by the occurrence of ischemic stroke, is often reviewed on its vascular side, and parenchymal consequences are put aside. Here, we sought to review the impact of isolated hypertension or hypertension associated to stroke on brain atrophy, neuron connectivity and neurogenesis, and phenotype modification of microglia and astrocytes. Finally, we discuss the impact of antihypertensive therapies on cell responses to hypertension and functional recovery. This attractive topic remains a focus of continued investigation and stresses the relevance of including this vascular risk factor in preclinical investigations of stroke outcome.
format Online
Article
Text
id pubmed-6815533
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-68155332019-11-17 Hypertension and Its Impact on Stroke Recovery: From a Vascular to a Parenchymal Overview Maïer, Benjamin Kubis, Nathalie Neural Plast Review Article Hypertension is the first modifiable vascular risk factor accounting for 10.4 million deaths worldwide; it is strongly and independently associated with the risk of stroke and is related to worse prognosis. In addition, hypertension seems to be a key player in the implementation of vascular cognitive impairment. Long-term hypertension, complicated or not by the occurrence of ischemic stroke, is often reviewed on its vascular side, and parenchymal consequences are put aside. Here, we sought to review the impact of isolated hypertension or hypertension associated to stroke on brain atrophy, neuron connectivity and neurogenesis, and phenotype modification of microglia and astrocytes. Finally, we discuss the impact of antihypertensive therapies on cell responses to hypertension and functional recovery. This attractive topic remains a focus of continued investigation and stresses the relevance of including this vascular risk factor in preclinical investigations of stroke outcome. Hindawi 2019-10-14 /pmc/articles/PMC6815533/ /pubmed/31737062 http://dx.doi.org/10.1155/2019/6843895 Text en Copyright © 2019 Benjamin Maïer and Nathalie Kubis. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Maïer, Benjamin
Kubis, Nathalie
Hypertension and Its Impact on Stroke Recovery: From a Vascular to a Parenchymal Overview
title Hypertension and Its Impact on Stroke Recovery: From a Vascular to a Parenchymal Overview
title_full Hypertension and Its Impact on Stroke Recovery: From a Vascular to a Parenchymal Overview
title_fullStr Hypertension and Its Impact on Stroke Recovery: From a Vascular to a Parenchymal Overview
title_full_unstemmed Hypertension and Its Impact on Stroke Recovery: From a Vascular to a Parenchymal Overview
title_short Hypertension and Its Impact on Stroke Recovery: From a Vascular to a Parenchymal Overview
title_sort hypertension and its impact on stroke recovery: from a vascular to a parenchymal overview
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815533/
https://www.ncbi.nlm.nih.gov/pubmed/31737062
http://dx.doi.org/10.1155/2019/6843895
work_keys_str_mv AT maierbenjamin hypertensionanditsimpactonstrokerecoveryfromavasculartoaparenchymaloverview
AT kubisnathalie hypertensionanditsimpactonstrokerecoveryfromavasculartoaparenchymaloverview