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Hypertension and Its Impact on Stroke Recovery: From a Vascular to a Parenchymal Overview
Hypertension is the first modifiable vascular risk factor accounting for 10.4 million deaths worldwide; it is strongly and independently associated with the risk of stroke and is related to worse prognosis. In addition, hypertension seems to be a key player in the implementation of vascular cognitiv...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815533/ https://www.ncbi.nlm.nih.gov/pubmed/31737062 http://dx.doi.org/10.1155/2019/6843895 |
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author | Maïer, Benjamin Kubis, Nathalie |
author_facet | Maïer, Benjamin Kubis, Nathalie |
author_sort | Maïer, Benjamin |
collection | PubMed |
description | Hypertension is the first modifiable vascular risk factor accounting for 10.4 million deaths worldwide; it is strongly and independently associated with the risk of stroke and is related to worse prognosis. In addition, hypertension seems to be a key player in the implementation of vascular cognitive impairment. Long-term hypertension, complicated or not by the occurrence of ischemic stroke, is often reviewed on its vascular side, and parenchymal consequences are put aside. Here, we sought to review the impact of isolated hypertension or hypertension associated to stroke on brain atrophy, neuron connectivity and neurogenesis, and phenotype modification of microglia and astrocytes. Finally, we discuss the impact of antihypertensive therapies on cell responses to hypertension and functional recovery. This attractive topic remains a focus of continued investigation and stresses the relevance of including this vascular risk factor in preclinical investigations of stroke outcome. |
format | Online Article Text |
id | pubmed-6815533 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-68155332019-11-17 Hypertension and Its Impact on Stroke Recovery: From a Vascular to a Parenchymal Overview Maïer, Benjamin Kubis, Nathalie Neural Plast Review Article Hypertension is the first modifiable vascular risk factor accounting for 10.4 million deaths worldwide; it is strongly and independently associated with the risk of stroke and is related to worse prognosis. In addition, hypertension seems to be a key player in the implementation of vascular cognitive impairment. Long-term hypertension, complicated or not by the occurrence of ischemic stroke, is often reviewed on its vascular side, and parenchymal consequences are put aside. Here, we sought to review the impact of isolated hypertension or hypertension associated to stroke on brain atrophy, neuron connectivity and neurogenesis, and phenotype modification of microglia and astrocytes. Finally, we discuss the impact of antihypertensive therapies on cell responses to hypertension and functional recovery. This attractive topic remains a focus of continued investigation and stresses the relevance of including this vascular risk factor in preclinical investigations of stroke outcome. Hindawi 2019-10-14 /pmc/articles/PMC6815533/ /pubmed/31737062 http://dx.doi.org/10.1155/2019/6843895 Text en Copyright © 2019 Benjamin Maïer and Nathalie Kubis. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Maïer, Benjamin Kubis, Nathalie Hypertension and Its Impact on Stroke Recovery: From a Vascular to a Parenchymal Overview |
title | Hypertension and Its Impact on Stroke Recovery: From a Vascular to a Parenchymal Overview |
title_full | Hypertension and Its Impact on Stroke Recovery: From a Vascular to a Parenchymal Overview |
title_fullStr | Hypertension and Its Impact on Stroke Recovery: From a Vascular to a Parenchymal Overview |
title_full_unstemmed | Hypertension and Its Impact on Stroke Recovery: From a Vascular to a Parenchymal Overview |
title_short | Hypertension and Its Impact on Stroke Recovery: From a Vascular to a Parenchymal Overview |
title_sort | hypertension and its impact on stroke recovery: from a vascular to a parenchymal overview |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815533/ https://www.ncbi.nlm.nih.gov/pubmed/31737062 http://dx.doi.org/10.1155/2019/6843895 |
work_keys_str_mv | AT maierbenjamin hypertensionanditsimpactonstrokerecoveryfromavasculartoaparenchymaloverview AT kubisnathalie hypertensionanditsimpactonstrokerecoveryfromavasculartoaparenchymaloverview |