LncRNA LEGLTBC Functions as a ceRNA to Antagonize the Effects of miR-34a on the Downregulation of SIRT1 in Glucolipotoxicity-Induced INS-1 Beta Cell Oxidative Stress and Apoptosis

Type 2 diabetes mellitus is a chronic metabolic disorder characterized by elevated blood glucose and/or high serum free fatty acids. Chronic hyperlipidemia causes the dysfunction of pancreatic beta cells, which is aggravated in the presence of hyperglycemia (glucolipotoxicity). Long noncoding RNAs (...

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Detalles Bibliográficos
Autores principales: Kong, Xiang, Liu, Chong-xiao, Wang, Guo-dong, Yang, Hui, Yao, Xin-ming, Hua, Qiang, Li, Xiao-yong, Zhang, Hong-mei, Ma, Ming-zhe, Su, Qing, Lv, Kun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815544/
https://www.ncbi.nlm.nih.gov/pubmed/31737170
http://dx.doi.org/10.1155/2019/4010764

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