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A Unique Case of IGF-2 Induced Hypoglycemia Associated with Hepatocellular Carcinoma

Tumor-induced hypoglycemia (TIH) associated with hepatocellular carcinoma (HCC) results from tumor production of insulin-like growth factor 2 (IGF-2), resulting in recurrent hypoglycemia. Serum levels of insulin-like growth factor 1 (IGF-1), insulin-like growth factor 2 (IGF-2), or pro-insulin-like...

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Detalles Bibliográficos
Autores principales: Rana, Prachi, Kim, Brian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815553/
https://www.ncbi.nlm.nih.gov/pubmed/31737377
http://dx.doi.org/10.1155/2019/4601484
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author Rana, Prachi
Kim, Brian
author_facet Rana, Prachi
Kim, Brian
author_sort Rana, Prachi
collection PubMed
description Tumor-induced hypoglycemia (TIH) associated with hepatocellular carcinoma (HCC) results from tumor production of insulin-like growth factor 2 (IGF-2), resulting in recurrent hypoglycemia. Serum levels of insulin-like growth factor 1 (IGF-1), insulin-like growth factor 2 (IGF-2), or pro-insulin-like growth factor 2 (pro-IGF-2) are required for the diagnosis. However, due to the limited availability of testing in many laboratories, this condition is often overlooked. As this condition is often overlooked, prompt recognition and implementation of tumor directed therapies and/or systemic therapies can help mitigate the consequences of hypoglycemia. We present a 38-year-old man with advanced multifocal HCC who presented with abdominal pain and was found to have recurrent symptomatic hypoglycemia. Evaluation revealed elevated levels of IGF-2, suggesting a diagnosis of HCC with production of IGF-2.
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spelling pubmed-68155532019-11-17 A Unique Case of IGF-2 Induced Hypoglycemia Associated with Hepatocellular Carcinoma Rana, Prachi Kim, Brian Case Rep Endocrinol Case Report Tumor-induced hypoglycemia (TIH) associated with hepatocellular carcinoma (HCC) results from tumor production of insulin-like growth factor 2 (IGF-2), resulting in recurrent hypoglycemia. Serum levels of insulin-like growth factor 1 (IGF-1), insulin-like growth factor 2 (IGF-2), or pro-insulin-like growth factor 2 (pro-IGF-2) are required for the diagnosis. However, due to the limited availability of testing in many laboratories, this condition is often overlooked. As this condition is often overlooked, prompt recognition and implementation of tumor directed therapies and/or systemic therapies can help mitigate the consequences of hypoglycemia. We present a 38-year-old man with advanced multifocal HCC who presented with abdominal pain and was found to have recurrent symptomatic hypoglycemia. Evaluation revealed elevated levels of IGF-2, suggesting a diagnosis of HCC with production of IGF-2. Hindawi 2019-10-13 /pmc/articles/PMC6815553/ /pubmed/31737377 http://dx.doi.org/10.1155/2019/4601484 Text en Copyright © 2019 Prachi Rana and Brian Kim. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Rana, Prachi
Kim, Brian
A Unique Case of IGF-2 Induced Hypoglycemia Associated with Hepatocellular Carcinoma
title A Unique Case of IGF-2 Induced Hypoglycemia Associated with Hepatocellular Carcinoma
title_full A Unique Case of IGF-2 Induced Hypoglycemia Associated with Hepatocellular Carcinoma
title_fullStr A Unique Case of IGF-2 Induced Hypoglycemia Associated with Hepatocellular Carcinoma
title_full_unstemmed A Unique Case of IGF-2 Induced Hypoglycemia Associated with Hepatocellular Carcinoma
title_short A Unique Case of IGF-2 Induced Hypoglycemia Associated with Hepatocellular Carcinoma
title_sort unique case of igf-2 induced hypoglycemia associated with hepatocellular carcinoma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815553/
https://www.ncbi.nlm.nih.gov/pubmed/31737377
http://dx.doi.org/10.1155/2019/4601484
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