Cytotoxic Phenolic Compounds from Fruit Glandular Trichomes of Macaranga tanarius

A new flavonoid, macatanarin D (1), together with five known stilbenes (2-6), was isolated from fruit glandular trichomes of Macaranga tanarius. Their structures were elucidated on the basis of spectroscopic methods and through comparison with data reported in the literature. All isolated compounds...

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Detalles Bibliográficos
Autores principales: Doan, Thi Mai Huong, Nguyen, Thuy Linh, Trinh, Thi Thanh Van, Vu, Van Nam, Phi, Thi Dao, Litaudon, Marc, Roussi, Fanny, Chau, Van Minh, Pham, Van Cuong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815561/
https://www.ncbi.nlm.nih.gov/pubmed/31737404
http://dx.doi.org/10.1155/2019/2917032
Descripción
Sumario:A new flavonoid, macatanarin D (1), together with five known stilbenes (2-6), was isolated from fruit glandular trichomes of Macaranga tanarius. Their structures were elucidated on the basis of spectroscopic methods and through comparison with data reported in the literature. All isolated compounds were evaluated for their cytotoxic activities against KB and MCF-7 cell lines. Compounds 3, 4, and 5 showed the strongest activities against both cell lines with IC(50) values in the range of 0.03–0.12 μM, and compound 2 only showed a significant cytotoxicity against KB cell line (IC(50) = 0.26 μM) and a moderate cytotoxicity against MCF-7 (IC(50) = 10.4 μM). Compounds 1 and 6 showed weak cytotoxic activities against KB cell line with IC(50) values of 29.3 and 24.7 μM, respectively.

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