Hyperinsulinemia Can Cause Kidney Disease in the IGT Stage of OLETF Rats via the INS/IRS-1/PI3-K/Akt Signaling Pathway

AIMS: We investigated the changes of renal structure and its function in normal glucose tolerance (NGT), impaired glucose tolerance (IGT), diabetes mellitus (DM), and diabetic kidney disease (DKD) stages in OLETF rats and explored the role of the INS/IRS-1/PI3-K/Akt signaling pathway. METHODS: OLETF...

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Detalles Bibliográficos
Autores principales: Zhang, Yi, Yang, Shaohua, Cui, Xiao, Yang, Juhong, Zheng, Miaoyan, Jia, Junya, Han, Fei, Yang, Xiaoyun, Wang, Jingyu, Guo, Zhenhong, Chang, Bai, Chang, Baocheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815570/
https://www.ncbi.nlm.nih.gov/pubmed/31737684
http://dx.doi.org/10.1155/2019/4709715

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815570/
https://www.ncbi.nlm.nih.gov/pubmed/31737684
http://dx.doi.org/10.1155/2019/4709715

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