Cargando…

Hyperinsulinemia Can Cause Kidney Disease in the IGT Stage of OLETF Rats via the INS/IRS-1/PI3-K/Akt Signaling Pathway

AIMS: We investigated the changes of renal structure and its function in normal glucose tolerance (NGT), impaired glucose tolerance (IGT), diabetes mellitus (DM), and diabetic kidney disease (DKD) stages in OLETF rats and explored the role of the INS/IRS-1/PI3-K/Akt signaling pathway. METHODS: OLETF...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Yi, Yang, Shaohua, Cui, Xiao, Yang, Juhong, Zheng, Miaoyan, Jia, Junya, Han, Fei, Yang, Xiaoyun, Wang, Jingyu, Guo, Zhenhong, Chang, Bai, Chang, Baocheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815570/ https://www.ncbi.nlm.nih.gov/pubmed/31737684 http://dx.doi.org/10.1155/2019/4709715

Ejemplares similares

Retinal Neuropathy in IGT Stage of OLETF Rats: Another Characteristic Change of Diabetic Retinopathy
por: Guo, Zhenhong, et al.
Publicado: (2021)

Salsalate Prevents β-Cell Dedifferentiation in OLETF Rats with Type 2 Diabetes through Notch1 Pathway
por: Han, Fei, et al.
Publicado: (2019)

Pathological Hyperinsulinemia and Hyperglycemia in the Impaired Glucose Tolerance Stage Mediate Endothelial Dysfunction Through miR-21, PTEN/AKT/eNOS, and MARK/ET-1 Pathways
por: Liu, Ran, et al.
Publicado: (2021)

Hyperinsulinemia impairs the metabolic switch to ketone body utilization in proximal renal tubular epithelial cells under energy crisis via the inhibition of the SIRT3/SMCT1 pathway
por: Xie, Jinlan, et al.
Publicado: (2022)

Atorvastatin inhibits insulin synthesis by inhibiting the Ras/Raf/ERK/CREB pathway in INS-1 cells
por: Sun, Hongxi, et al.
Publicado: (2016)

Hyperinsulinemia contributes to impaired-glucose-tolerance-induced renal injury via mir-7977/SIRT3 signaling
por: Gao, Zhongai, et al.
Publicado: (2020)

Iowa Gambling Task (IGT): twenty years after – gambling disorder and IGT
por: Brevers, Damien, et al.
Publicado: (2013)

Editorial: Rising stars in renal endocrinology: 2021
por: Yang, Juhong, et al.
Publicado: (2023)

Effects of metformin and sitagliptin on glycolipid metabolism in type 2 diabetic rats on different diets
por: Yang, Juhong, et al.
Publicado: (2016)

Beta-Hydroxybutyric Acid Inhibits Renal Tubular Reabsorption via the AKT/DAB2/Megalin Signalling Pathway
por: Zuo, Minxia, et al.
Publicado: (2022)

Recent advances in computational electromagnetics (IGTE 2016)
por: Sykulski, Jan, et al.
Publicado: (2017)

Immune response to Ichthyophthirius multifiliis and role of IgT
por: Buchmann, Kurt
Publicado: (2019)

Beneficial Effects of Thiazolidinediones on Diabetic Nephropathy in OLETF Rats
por: Lee, Mi Young, et al.
Publicado: (2007)

Microarray for Genes Associated with Signal Transduction in Diabetic OLETF Keratocytes
por: Lee, Ji-Eun, et al.
Publicado: (2007)

Microarray Analysis for Genes Associated with Angiogenesis in Diabetic OLETF Keratocytes
por: Park, Jun-Mo, et al.
Publicado: (2014)

The $\pi^{-}-\pi^{0}$ mass difference ins
por: Hillman, Peter, et al.
Publicado: (1959)

Learning on the IGT follows emergence of knowledge but not differential somatic activity
por: Fernie, Gordon, et al.
Publicado: (2013)

Effect of dietary resveratrol on the metabolic profile of nutrients in obese OLETF rats
por: Nagao, Koji, et al.
Publicado: (2013)

Genetic Dissection of Complex Genetic Factor Involved in NIDDM of OLETF Rat
por: Yamada, Takahisa, et al.
Publicado: (2012)

Effects of early postnatal environment on hypothalamic gene expression in OLETF rats
por: Kim, Yonwook J., et al.
Publicado: (2017)

Hyperinsulinemia Associated Depression
por: Sarwar, Haider, et al.
Publicado: (2022)

Characteristics of members of IGT family genes in controlling rice root system architecture and tiller development
por: Zhao, Jianping, et al.
Publicado: (2022)

Cancer and its predictors in Chinese adults with newly diagnosed diabetes and impaired glucose tolerance (IGT): a 30-year follow-up of the Da Qing IGT and Diabetes Study
por: He, Siyao, et al.
Publicado: (2022)

Preventive Role of Salsalate in Diabetes Is Associated With Reducing Intestinal Inflammation Through Improvement of Gut Dysbiosis in ZDF Rats
por: Zhang, Xinrong, et al.
Publicado: (2020)

An Atherogenic Paigen-Diet Aggravates Nephropathy in Type 2 Diabetic OLETF Rats
por: Nozako, Masanori, et al.
Publicado: (2015)

Immunoglobulin Tau Heavy Chain (IgT) in Flounder, Paralichthys olivaceus: Molecular Cloning, Characterization, and Expression Analyses
por: Du, Yang, et al.
Publicado: (2016)

Acute Hyperglycemia May Induce Renal Tubular Injury Through Mitophagy Inhibition
por: Wang, Jingyu, et al.
Publicado: (2020)

3rd International IGTE Symposium on Numerical Field Calculation in Electrical Engineering
Publicado: (1988)

Performance Under Stress: An Eye-Tracking Investigation of the Iowa Gambling Task (IGT)
por: Simonovic, Boban, et al.
Publicado: (2018)

Effects of hyperinsulinemia on acquired resistance to epidermal growth factor receptor-tyrosine kinase inhibitor via the PI3K/AKT pathway in non-small cell lung cancer cells in vitro
por: Chiu, Hsin-Yi, et al.
Publicado: (2020)

Mechanism of the mitogenic influence of hyperinsulinemia
por: Draznin, Boris
Publicado: (2011)

21 hypoglycemia cases with hyperinsulinemia
por: Mizuno, Yusuke, et al.
Publicado: (2013)

Hyperinsulinemia: a Cause of Obesity?
por: Erion, Karel A., et al.
Publicado: (2017)

The Effects of Hyperinsulinemia on Cochlear Functions
por: Or Koca, Arzu, et al.
Publicado: (2020)

Hyperinsulinemia in Obesity, Inflammation, and Cancer
por: Zhang, Anni M.Y., et al.
Publicado: (2021)

Hyperinsulinemia in Obesity, Inflammation, and Cancer
por: Zhang, Anni M.Y., et al.
Publicado: (2021)

Downregulation of macrophage Irs2 by hyperinsulinemia impairs IL-4-indeuced M2a-subtype macrophage activation in obesity
por: Kubota, Tetsuya, et al.
Publicado: (2018)

Low pH of interstitial fluid around hippocampus of the brain in diabetic OLETF rats
por: Marunaka, Yoshinori, et al.
Publicado: (2014)

Chronic hyperinsulinemia promotes human hepatocyte senescence
por: Baboota, Ritesh K., et al.
Publicado: (2022)

miR-431 regulates granulosa cell function through the IRS2/PI3K/AKT signaling pathway
por: YANG, Lei, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_em7l8rdfp7tiq59g90mtjhn3b9