Keap1 Cystenine 151 as a Potential Target for Artemisitene-Induced Nrf2 Activation

Artemisitene (ATT) activates the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) by increasing its stabilization and reducing ubiquitination. The cysteine (Cys) residues of the cytosolic Nrf2 repressor Kelch-like ECH-associated protein-1 (Keap1) function as redox sensors and may be crucial in act...

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Detalles Bibliográficos
Autores principales: Liu, Shanshan, Xu, Shengmei, Wei, Renrong, Cui, Zhizhong, Wu, Xiaoyun, Wei, Renxiong, Xie, Li, Zhou, Yingye, Li, Wenjuan, Chen, Weimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815614/
https://www.ncbi.nlm.nih.gov/pubmed/31737667
http://dx.doi.org/10.1155/2019/5198138

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