Severe Human Intestinal Spirochetosis: An Unusual Cause of Diffuse Colonic Ulcerations in a Patient Living with HIV

We describe a case of a homosexual male with human immunodeficiency virus (HIV) and CD4 count of 246 presenting with acute severe bloody diarrhea. Infectious work up was negative, and colonoscopy revealed severe diffuse colonic ulcerations. Histopathologic analysis and Treponemal pallidum immunostai...

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Autores principales: Ajose, T. A., Aniekwena, J., Effoe, V. S., Simien, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815633/
https://www.ncbi.nlm.nih.gov/pubmed/31737379
http://dx.doi.org/10.1155/2019/1504079
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author Ajose, T. A.
Aniekwena, J.
Effoe, V. S.
Simien, M.
author_facet Ajose, T. A.
Aniekwena, J.
Effoe, V. S.
Simien, M.
author_sort Ajose, T. A.
collection PubMed
description We describe a case of a homosexual male with human immunodeficiency virus (HIV) and CD4 count of 246 presenting with acute severe bloody diarrhea. Infectious work up was negative, and colonoscopy revealed severe diffuse colonic ulcerations. Histopathologic analysis and Treponemal pallidum immunostaining confirmed the diagnosis of intestinal spirochetosis. There was no evidence of co-infection with other pathogens. His symptoms completely resolved after a 14-day course of metronidazole. This case is notable as colonic ulceration of any severity in patients living with HIV is rarely identified with intestinal spirochetosis. Hence, it should be considered in the differential diagnosis of colonic ulcerations.
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spelling pubmed-68156332019-11-17 Severe Human Intestinal Spirochetosis: An Unusual Cause of Diffuse Colonic Ulcerations in a Patient Living with HIV Ajose, T. A. Aniekwena, J. Effoe, V. S. Simien, M. Case Rep Gastrointest Med Case Report We describe a case of a homosexual male with human immunodeficiency virus (HIV) and CD4 count of 246 presenting with acute severe bloody diarrhea. Infectious work up was negative, and colonoscopy revealed severe diffuse colonic ulcerations. Histopathologic analysis and Treponemal pallidum immunostaining confirmed the diagnosis of intestinal spirochetosis. There was no evidence of co-infection with other pathogens. His symptoms completely resolved after a 14-day course of metronidazole. This case is notable as colonic ulceration of any severity in patients living with HIV is rarely identified with intestinal spirochetosis. Hence, it should be considered in the differential diagnosis of colonic ulcerations. Hindawi 2019-10-15 /pmc/articles/PMC6815633/ /pubmed/31737379 http://dx.doi.org/10.1155/2019/1504079 Text en Copyright © 2019 T. A. Ajose et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Ajose, T. A.
Aniekwena, J.
Effoe, V. S.
Simien, M.
Severe Human Intestinal Spirochetosis: An Unusual Cause of Diffuse Colonic Ulcerations in a Patient Living with HIV
title Severe Human Intestinal Spirochetosis: An Unusual Cause of Diffuse Colonic Ulcerations in a Patient Living with HIV
title_full Severe Human Intestinal Spirochetosis: An Unusual Cause of Diffuse Colonic Ulcerations in a Patient Living with HIV
title_fullStr Severe Human Intestinal Spirochetosis: An Unusual Cause of Diffuse Colonic Ulcerations in a Patient Living with HIV
title_full_unstemmed Severe Human Intestinal Spirochetosis: An Unusual Cause of Diffuse Colonic Ulcerations in a Patient Living with HIV
title_short Severe Human Intestinal Spirochetosis: An Unusual Cause of Diffuse Colonic Ulcerations in a Patient Living with HIV
title_sort severe human intestinal spirochetosis: an unusual cause of diffuse colonic ulcerations in a patient living with hiv
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815633/
https://www.ncbi.nlm.nih.gov/pubmed/31737379
http://dx.doi.org/10.1155/2019/1504079
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