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Prevalence and determinants of type 2 diabetes among lean African migrants and non-migrants: the RODAM study

BACKGROUND: Exposure to adverse conditions earlier in life-course can predispose to type 2 diabetes in adulthood, irrespective of body mass index (BMI). However, the burden of type 2 diabetes in lean Africans is not well understood despite higher exposure to adverse early life conditions. Mirroring...

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Autores principales: Chilunga, Felix P, Henneman, Peter, Meeks, Karlijn AC, Beune, Erik, Requena-Méndez, Ana, Smeeth, Liam, Addo, Juliet, Bahendeka, Silver, Danquah, Ina, Schulze, Matthias B, Spranger, Joachim, Owusu-Dabo, Ellis, Klipstein-Grobusch, Kerstin, Mannens, Marcel MAM, Agyemang, Charles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Edinburgh University Global Health Society 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815658/
https://www.ncbi.nlm.nih.gov/pubmed/31673340
http://dx.doi.org/10.7189/jogh.09.020426
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author Chilunga, Felix P
Henneman, Peter
Meeks, Karlijn AC
Beune, Erik
Requena-Méndez, Ana
Smeeth, Liam
Addo, Juliet
Bahendeka, Silver
Danquah, Ina
Schulze, Matthias B
Spranger, Joachim
Owusu-Dabo, Ellis
Klipstein-Grobusch, Kerstin
Mannens, Marcel MAM
Agyemang, Charles
author_facet Chilunga, Felix P
Henneman, Peter
Meeks, Karlijn AC
Beune, Erik
Requena-Méndez, Ana
Smeeth, Liam
Addo, Juliet
Bahendeka, Silver
Danquah, Ina
Schulze, Matthias B
Spranger, Joachim
Owusu-Dabo, Ellis
Klipstein-Grobusch, Kerstin
Mannens, Marcel MAM
Agyemang, Charles
author_sort Chilunga, Felix P
collection PubMed
description BACKGROUND: Exposure to adverse conditions earlier in life-course can predispose to type 2 diabetes in adulthood, irrespective of body mass index (BMI). However, the burden of type 2 diabetes in lean Africans is not well understood despite higher exposure to adverse early life conditions. Mirroring ongoing epidemiological transition, we assessed the burden and determinants of type 2 diabetes in a homogenous group of lean Ghanaians residing in rural and urban Ghana, and as migrants in Europe. METHODS: Baseline data from 2179 RODAM study participants with BMI<25kg/m(2) (25-70 years) were analyzed. Prevalence and determinants of type 2 diabetes were estimated using logistic regression analysis. Adjustments were made for socio-demographic and lifestyle factors, use of anti-diabetic medication and optimal blood glucose control. RESULTS: Prevalence of type 2 diabetes in rural, urban and migrant lean participants were 3.5%, 8.9% and 7.5% respectively, representing 55.4%, 35.6%, 13.2% of all participants with type 2 diabetes. Compared with lean rural participants, the odds of type 2 diabetes were higher in lean urban participants (adjusted OR = 8.81, 95% CI = 6.56-11.06), followed by migrants (5.27, 95% CI = 3.51-6.91). Irrespective of site, determinants of type 2 diabetes in lean participants include; presence of hypertension, physical inactivity, hypercholesterolemia and age (>45 years). CONCLUSIONS: Our study shows a high prevalence of type 2 diabetes among lean African populations in different geographical settings. Future studies are needed in-order to examine how contextual differences are related to the pathophysiology of type 2 diabetes in lean individuals.
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spelling pubmed-68156582019-10-31 Prevalence and determinants of type 2 diabetes among lean African migrants and non-migrants: the RODAM study Chilunga, Felix P Henneman, Peter Meeks, Karlijn AC Beune, Erik Requena-Méndez, Ana Smeeth, Liam Addo, Juliet Bahendeka, Silver Danquah, Ina Schulze, Matthias B Spranger, Joachim Owusu-Dabo, Ellis Klipstein-Grobusch, Kerstin Mannens, Marcel MAM Agyemang, Charles J Glob Health Articles BACKGROUND: Exposure to adverse conditions earlier in life-course can predispose to type 2 diabetes in adulthood, irrespective of body mass index (BMI). However, the burden of type 2 diabetes in lean Africans is not well understood despite higher exposure to adverse early life conditions. Mirroring ongoing epidemiological transition, we assessed the burden and determinants of type 2 diabetes in a homogenous group of lean Ghanaians residing in rural and urban Ghana, and as migrants in Europe. METHODS: Baseline data from 2179 RODAM study participants with BMI<25kg/m(2) (25-70 years) were analyzed. Prevalence and determinants of type 2 diabetes were estimated using logistic regression analysis. Adjustments were made for socio-demographic and lifestyle factors, use of anti-diabetic medication and optimal blood glucose control. RESULTS: Prevalence of type 2 diabetes in rural, urban and migrant lean participants were 3.5%, 8.9% and 7.5% respectively, representing 55.4%, 35.6%, 13.2% of all participants with type 2 diabetes. Compared with lean rural participants, the odds of type 2 diabetes were higher in lean urban participants (adjusted OR = 8.81, 95% CI = 6.56-11.06), followed by migrants (5.27, 95% CI = 3.51-6.91). Irrespective of site, determinants of type 2 diabetes in lean participants include; presence of hypertension, physical inactivity, hypercholesterolemia and age (>45 years). CONCLUSIONS: Our study shows a high prevalence of type 2 diabetes among lean African populations in different geographical settings. Future studies are needed in-order to examine how contextual differences are related to the pathophysiology of type 2 diabetes in lean individuals. Edinburgh University Global Health Society 2019-12 2019-10-22 /pmc/articles/PMC6815658/ /pubmed/31673340 http://dx.doi.org/10.7189/jogh.09.020426 Text en Copyright © 2019 by the Journal of Global Health. All rights reserved. http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License.
spellingShingle Articles
Chilunga, Felix P
Henneman, Peter
Meeks, Karlijn AC
Beune, Erik
Requena-Méndez, Ana
Smeeth, Liam
Addo, Juliet
Bahendeka, Silver
Danquah, Ina
Schulze, Matthias B
Spranger, Joachim
Owusu-Dabo, Ellis
Klipstein-Grobusch, Kerstin
Mannens, Marcel MAM
Agyemang, Charles
Prevalence and determinants of type 2 diabetes among lean African migrants and non-migrants: the RODAM study
title Prevalence and determinants of type 2 diabetes among lean African migrants and non-migrants: the RODAM study
title_full Prevalence and determinants of type 2 diabetes among lean African migrants and non-migrants: the RODAM study
title_fullStr Prevalence and determinants of type 2 diabetes among lean African migrants and non-migrants: the RODAM study
title_full_unstemmed Prevalence and determinants of type 2 diabetes among lean African migrants and non-migrants: the RODAM study
title_short Prevalence and determinants of type 2 diabetes among lean African migrants and non-migrants: the RODAM study
title_sort prevalence and determinants of type 2 diabetes among lean african migrants and non-migrants: the rodam study
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815658/
https://www.ncbi.nlm.nih.gov/pubmed/31673340
http://dx.doi.org/10.7189/jogh.09.020426
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