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Prevalence and determinants of type 2 diabetes among lean African migrants and non-migrants: the RODAM study
BACKGROUND: Exposure to adverse conditions earlier in life-course can predispose to type 2 diabetes in adulthood, irrespective of body mass index (BMI). However, the burden of type 2 diabetes in lean Africans is not well understood despite higher exposure to adverse early life conditions. Mirroring...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Edinburgh University Global Health Society
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815658/ https://www.ncbi.nlm.nih.gov/pubmed/31673340 http://dx.doi.org/10.7189/jogh.09.020426 |
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author | Chilunga, Felix P Henneman, Peter Meeks, Karlijn AC Beune, Erik Requena-Méndez, Ana Smeeth, Liam Addo, Juliet Bahendeka, Silver Danquah, Ina Schulze, Matthias B Spranger, Joachim Owusu-Dabo, Ellis Klipstein-Grobusch, Kerstin Mannens, Marcel MAM Agyemang, Charles |
author_facet | Chilunga, Felix P Henneman, Peter Meeks, Karlijn AC Beune, Erik Requena-Méndez, Ana Smeeth, Liam Addo, Juliet Bahendeka, Silver Danquah, Ina Schulze, Matthias B Spranger, Joachim Owusu-Dabo, Ellis Klipstein-Grobusch, Kerstin Mannens, Marcel MAM Agyemang, Charles |
author_sort | Chilunga, Felix P |
collection | PubMed |
description | BACKGROUND: Exposure to adverse conditions earlier in life-course can predispose to type 2 diabetes in adulthood, irrespective of body mass index (BMI). However, the burden of type 2 diabetes in lean Africans is not well understood despite higher exposure to adverse early life conditions. Mirroring ongoing epidemiological transition, we assessed the burden and determinants of type 2 diabetes in a homogenous group of lean Ghanaians residing in rural and urban Ghana, and as migrants in Europe. METHODS: Baseline data from 2179 RODAM study participants with BMI<25kg/m(2) (25-70 years) were analyzed. Prevalence and determinants of type 2 diabetes were estimated using logistic regression analysis. Adjustments were made for socio-demographic and lifestyle factors, use of anti-diabetic medication and optimal blood glucose control. RESULTS: Prevalence of type 2 diabetes in rural, urban and migrant lean participants were 3.5%, 8.9% and 7.5% respectively, representing 55.4%, 35.6%, 13.2% of all participants with type 2 diabetes. Compared with lean rural participants, the odds of type 2 diabetes were higher in lean urban participants (adjusted OR = 8.81, 95% CI = 6.56-11.06), followed by migrants (5.27, 95% CI = 3.51-6.91). Irrespective of site, determinants of type 2 diabetes in lean participants include; presence of hypertension, physical inactivity, hypercholesterolemia and age (>45 years). CONCLUSIONS: Our study shows a high prevalence of type 2 diabetes among lean African populations in different geographical settings. Future studies are needed in-order to examine how contextual differences are related to the pathophysiology of type 2 diabetes in lean individuals. |
format | Online Article Text |
id | pubmed-6815658 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Edinburgh University Global Health Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-68156582019-10-31 Prevalence and determinants of type 2 diabetes among lean African migrants and non-migrants: the RODAM study Chilunga, Felix P Henneman, Peter Meeks, Karlijn AC Beune, Erik Requena-Méndez, Ana Smeeth, Liam Addo, Juliet Bahendeka, Silver Danquah, Ina Schulze, Matthias B Spranger, Joachim Owusu-Dabo, Ellis Klipstein-Grobusch, Kerstin Mannens, Marcel MAM Agyemang, Charles J Glob Health Articles BACKGROUND: Exposure to adverse conditions earlier in life-course can predispose to type 2 diabetes in adulthood, irrespective of body mass index (BMI). However, the burden of type 2 diabetes in lean Africans is not well understood despite higher exposure to adverse early life conditions. Mirroring ongoing epidemiological transition, we assessed the burden and determinants of type 2 diabetes in a homogenous group of lean Ghanaians residing in rural and urban Ghana, and as migrants in Europe. METHODS: Baseline data from 2179 RODAM study participants with BMI<25kg/m(2) (25-70 years) were analyzed. Prevalence and determinants of type 2 diabetes were estimated using logistic regression analysis. Adjustments were made for socio-demographic and lifestyle factors, use of anti-diabetic medication and optimal blood glucose control. RESULTS: Prevalence of type 2 diabetes in rural, urban and migrant lean participants were 3.5%, 8.9% and 7.5% respectively, representing 55.4%, 35.6%, 13.2% of all participants with type 2 diabetes. Compared with lean rural participants, the odds of type 2 diabetes were higher in lean urban participants (adjusted OR = 8.81, 95% CI = 6.56-11.06), followed by migrants (5.27, 95% CI = 3.51-6.91). Irrespective of site, determinants of type 2 diabetes in lean participants include; presence of hypertension, physical inactivity, hypercholesterolemia and age (>45 years). CONCLUSIONS: Our study shows a high prevalence of type 2 diabetes among lean African populations in different geographical settings. Future studies are needed in-order to examine how contextual differences are related to the pathophysiology of type 2 diabetes in lean individuals. Edinburgh University Global Health Society 2019-12 2019-10-22 /pmc/articles/PMC6815658/ /pubmed/31673340 http://dx.doi.org/10.7189/jogh.09.020426 Text en Copyright © 2019 by the Journal of Global Health. All rights reserved. http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. |
spellingShingle | Articles Chilunga, Felix P Henneman, Peter Meeks, Karlijn AC Beune, Erik Requena-Méndez, Ana Smeeth, Liam Addo, Juliet Bahendeka, Silver Danquah, Ina Schulze, Matthias B Spranger, Joachim Owusu-Dabo, Ellis Klipstein-Grobusch, Kerstin Mannens, Marcel MAM Agyemang, Charles Prevalence and determinants of type 2 diabetes among lean African migrants and non-migrants: the RODAM study |
title | Prevalence and determinants of type 2 diabetes among lean African migrants and non-migrants: the RODAM study |
title_full | Prevalence and determinants of type 2 diabetes among lean African migrants and non-migrants: the RODAM study |
title_fullStr | Prevalence and determinants of type 2 diabetes among lean African migrants and non-migrants: the RODAM study |
title_full_unstemmed | Prevalence and determinants of type 2 diabetes among lean African migrants and non-migrants: the RODAM study |
title_short | Prevalence and determinants of type 2 diabetes among lean African migrants and non-migrants: the RODAM study |
title_sort | prevalence and determinants of type 2 diabetes among lean african migrants and non-migrants: the rodam study |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815658/ https://www.ncbi.nlm.nih.gov/pubmed/31673340 http://dx.doi.org/10.7189/jogh.09.020426 |
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