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The efficacy of a newly developed neurokinin 3 receptor agonist B21-750 on luteinizing hormone secretion in cycling goats
This study aimed to investigate the efficacy of a newly developed NK3 receptor agonist (B21-750) on the secretion of luteinizing hormone (LH) in association with ovarian steroid hormones during the follicular phase (FP, n = 5) and luteal phase (LP, n = 5) of Shiba goats. The FP group was treated wit...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Society for Reproduction and Development
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815734/ https://www.ncbi.nlm.nih.gov/pubmed/31406028 http://dx.doi.org/10.1262/jrd.2019-038 |
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author | RAHAYU, Larasati Puji ENDO, Natsumi KUWAI, Shinji OISHI, Shinya TANAKA, Tomomi |
author_facet | RAHAYU, Larasati Puji ENDO, Natsumi KUWAI, Shinji OISHI, Shinya TANAKA, Tomomi |
author_sort | RAHAYU, Larasati Puji |
collection | PubMed |
description | This study aimed to investigate the efficacy of a newly developed NK3 receptor agonist (B21-750) on the secretion of luteinizing hormone (LH) in association with ovarian steroid hormones during the follicular phase (FP, n = 5) and luteal phase (LP, n = 5) of Shiba goats. The FP group was treated with both prostaglandin F(2α) and progesterone-controlled internal drug release (CIDR) inserts for 10 d, and B21-750 (200 nmol) was injected 12 h after removing the CIDR. Meanwhile, the LP group received B21-750 injections on a day during the mid-luteal phase. LH secretion increased at 1 h after B21-750 injection in both groups. The percent changes in the area under the curve of LH was higher during the hour after injection than during the hour before injection in both groups. Thus, this study demonstrated that B21-750 induces rapid LH secretion for a short period during both the follicular and luteal phases. |
format | Online Article Text |
id | pubmed-6815734 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | The Society for Reproduction and Development |
record_format | MEDLINE/PubMed |
spelling | pubmed-68157342019-10-31 The efficacy of a newly developed neurokinin 3 receptor agonist B21-750 on luteinizing hormone secretion in cycling goats RAHAYU, Larasati Puji ENDO, Natsumi KUWAI, Shinji OISHI, Shinya TANAKA, Tomomi J Reprod Dev Technology Report This study aimed to investigate the efficacy of a newly developed NK3 receptor agonist (B21-750) on the secretion of luteinizing hormone (LH) in association with ovarian steroid hormones during the follicular phase (FP, n = 5) and luteal phase (LP, n = 5) of Shiba goats. The FP group was treated with both prostaglandin F(2α) and progesterone-controlled internal drug release (CIDR) inserts for 10 d, and B21-750 (200 nmol) was injected 12 h after removing the CIDR. Meanwhile, the LP group received B21-750 injections on a day during the mid-luteal phase. LH secretion increased at 1 h after B21-750 injection in both groups. The percent changes in the area under the curve of LH was higher during the hour after injection than during the hour before injection in both groups. Thus, this study demonstrated that B21-750 induces rapid LH secretion for a short period during both the follicular and luteal phases. The Society for Reproduction and Development 2019-08-12 2019-10 /pmc/articles/PMC6815734/ /pubmed/31406028 http://dx.doi.org/10.1262/jrd.2019-038 Text en ©2019 Society for Reproduction and Development This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/) |
spellingShingle | Technology Report RAHAYU, Larasati Puji ENDO, Natsumi KUWAI, Shinji OISHI, Shinya TANAKA, Tomomi The efficacy of a newly developed neurokinin 3 receptor agonist B21-750 on luteinizing hormone secretion in cycling goats |
title | The efficacy of a newly developed neurokinin 3 receptor agonist B21-750 on luteinizing hormone secretion in cycling goats |
title_full | The efficacy of a newly developed neurokinin 3 receptor agonist B21-750 on luteinizing hormone secretion in cycling goats |
title_fullStr | The efficacy of a newly developed neurokinin 3 receptor agonist B21-750 on luteinizing hormone secretion in cycling goats |
title_full_unstemmed | The efficacy of a newly developed neurokinin 3 receptor agonist B21-750 on luteinizing hormone secretion in cycling goats |
title_short | The efficacy of a newly developed neurokinin 3 receptor agonist B21-750 on luteinizing hormone secretion in cycling goats |
title_sort | efficacy of a newly developed neurokinin 3 receptor agonist b21-750 on luteinizing hormone secretion in cycling goats |
topic | Technology Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815734/ https://www.ncbi.nlm.nih.gov/pubmed/31406028 http://dx.doi.org/10.1262/jrd.2019-038 |
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