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STW 5 is effective against nonsteroidal anti-inflammatory drugs induced gastro-duodenal lesions in rats

BACKGROUND: Proton pump inhibitors are often used to prevent gastro-intestinal lesions induced by nonsteroidal anti-inflammatory drugs. However, they are not always effective against both gastric and duodenal lesions and their use is not devoid of side effects. AIM: To explore the mechanisms mediati...

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Autores principales: Khayyal, Mohamed T, Wadie, Walaa, Abd El-Haleim, Enas A, Ahmed, Kawkab A, Kelber, Olaf, Ammar, Ramy M, Abdel-Aziz, Heba
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815791/
https://www.ncbi.nlm.nih.gov/pubmed/31660030
http://dx.doi.org/10.3748/wjg.v25.i39.5926
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author Khayyal, Mohamed T
Wadie, Walaa
Abd El-Haleim, Enas A
Ahmed, Kawkab A
Kelber, Olaf
Ammar, Ramy M
Abdel-Aziz, Heba
author_facet Khayyal, Mohamed T
Wadie, Walaa
Abd El-Haleim, Enas A
Ahmed, Kawkab A
Kelber, Olaf
Ammar, Ramy M
Abdel-Aziz, Heba
author_sort Khayyal, Mohamed T
collection PubMed
description BACKGROUND: Proton pump inhibitors are often used to prevent gastro-intestinal lesions induced by nonsteroidal anti-inflammatory drugs. However, they are not always effective against both gastric and duodenal lesions and their use is not devoid of side effects. AIM: To explore the mechanisms mediating the clinical efficacy of STW 5 in gastro-duodenal lesions induced by nonsteroidal anti-inflammatory drugs (NSAIDs), exemplified here by diclofenac, in a comparison to omeprazole. METHODS: Gastro-duodenal lesions were induced in rats by oral administration of diclofenac (5 mg/kg) for 6 successive days. One group was given concurrently STW 5 (5 mL/kg) while another was given omeprazole (20 mg/kg). A day later, animals were sacrificed, stomach and duodenum excised and divided into 2 segments: One for histological examination and one for measuring inflammatory mediators (tumor necrosis factor α, interleukins-1β and 10), oxidative stress enzyme (heme oxygenase-1) and apoptosis regulator (B-cell lymphoma 2). RESULTS: Diclofenac caused overt histological damage in both tissues, associated with parallel changes in all parameters measured. STW 5 and omeprazole effectively prevented these changes, but STW 5 superseded omeprazole in protecting against histological damage, particularly in the duodenum. CONCLUSION: The findings support the therapeutic usefulness of STW 5 and its superiority over omeprazole as adjuvant therapy to NSAIDs to protect against their possible gastro-duodenal side effects.
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spelling pubmed-68157912019-10-28 STW 5 is effective against nonsteroidal anti-inflammatory drugs induced gastro-duodenal lesions in rats Khayyal, Mohamed T Wadie, Walaa Abd El-Haleim, Enas A Ahmed, Kawkab A Kelber, Olaf Ammar, Ramy M Abdel-Aziz, Heba World J Gastroenterol Basic Study BACKGROUND: Proton pump inhibitors are often used to prevent gastro-intestinal lesions induced by nonsteroidal anti-inflammatory drugs. However, they are not always effective against both gastric and duodenal lesions and their use is not devoid of side effects. AIM: To explore the mechanisms mediating the clinical efficacy of STW 5 in gastro-duodenal lesions induced by nonsteroidal anti-inflammatory drugs (NSAIDs), exemplified here by diclofenac, in a comparison to omeprazole. METHODS: Gastro-duodenal lesions were induced in rats by oral administration of diclofenac (5 mg/kg) for 6 successive days. One group was given concurrently STW 5 (5 mL/kg) while another was given omeprazole (20 mg/kg). A day later, animals were sacrificed, stomach and duodenum excised and divided into 2 segments: One for histological examination and one for measuring inflammatory mediators (tumor necrosis factor α, interleukins-1β and 10), oxidative stress enzyme (heme oxygenase-1) and apoptosis regulator (B-cell lymphoma 2). RESULTS: Diclofenac caused overt histological damage in both tissues, associated with parallel changes in all parameters measured. STW 5 and omeprazole effectively prevented these changes, but STW 5 superseded omeprazole in protecting against histological damage, particularly in the duodenum. CONCLUSION: The findings support the therapeutic usefulness of STW 5 and its superiority over omeprazole as adjuvant therapy to NSAIDs to protect against their possible gastro-duodenal side effects. Baishideng Publishing Group Inc 2019-10-21 2019-10-21 /pmc/articles/PMC6815791/ /pubmed/31660030 http://dx.doi.org/10.3748/wjg.v25.i39.5926 Text en ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Basic Study
Khayyal, Mohamed T
Wadie, Walaa
Abd El-Haleim, Enas A
Ahmed, Kawkab A
Kelber, Olaf
Ammar, Ramy M
Abdel-Aziz, Heba
STW 5 is effective against nonsteroidal anti-inflammatory drugs induced gastro-duodenal lesions in rats
title STW 5 is effective against nonsteroidal anti-inflammatory drugs induced gastro-duodenal lesions in rats
title_full STW 5 is effective against nonsteroidal anti-inflammatory drugs induced gastro-duodenal lesions in rats
title_fullStr STW 5 is effective against nonsteroidal anti-inflammatory drugs induced gastro-duodenal lesions in rats
title_full_unstemmed STW 5 is effective against nonsteroidal anti-inflammatory drugs induced gastro-duodenal lesions in rats
title_short STW 5 is effective against nonsteroidal anti-inflammatory drugs induced gastro-duodenal lesions in rats
title_sort stw 5 is effective against nonsteroidal anti-inflammatory drugs induced gastro-duodenal lesions in rats
topic Basic Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815791/
https://www.ncbi.nlm.nih.gov/pubmed/31660030
http://dx.doi.org/10.3748/wjg.v25.i39.5926
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