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Treatment of Gastric and Gastroesophageal Cancer Patients with Hemodialysis by CapeOX
Two patients underwent hemodialysis. Case 1 with stage IV gastric cancer was treated with reduced doses of capecitabine (1,000 mg/m(2)/day, days 1 to 14) and oxaliplatin (65 mg/m(2), day 1). Although grade 1 thrombocytopenia occurred in the first cycle, grade 3 thrombocytopenia developed in the seco...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Japanese Society of Internal Medicine
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815905/ https://www.ncbi.nlm.nih.gov/pubmed/31243213 http://dx.doi.org/10.2169/internalmedicine.2718-19 |
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author | Sasaki, Kenta Zhou, Qiliang Matsumoto, Yoshifumi Saiki, Takuro Moriyama, Masato Saijo, Yasuo |
author_facet | Sasaki, Kenta Zhou, Qiliang Matsumoto, Yoshifumi Saiki, Takuro Moriyama, Masato Saijo, Yasuo |
author_sort | Sasaki, Kenta |
collection | PubMed |
description | Two patients underwent hemodialysis. Case 1 with stage IV gastric cancer was treated with reduced doses of capecitabine (1,000 mg/m(2)/day, days 1 to 14) and oxaliplatin (65 mg/m(2), day 1). Although grade 1 thrombocytopenia occurred in the first cycle, grade 3 thrombocytopenia developed in the second cycle because of increasing dosage. After the dosage was reduced, chemotherapy was continued safely. Case 2 with stage IA gastroesophageal cancer was treated with radiotherapy followed by chemotherapy. Treatment with the same dose of CapeOX therapy as in case 1 resulted in no severe toxicity. We conclude that a half-dose of the CapeOX regimen is safe for gastric cancer patients undergoing hemodialysis. |
format | Online Article Text |
id | pubmed-6815905 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | The Japanese Society of Internal Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-68159052019-10-29 Treatment of Gastric and Gastroesophageal Cancer Patients with Hemodialysis by CapeOX Sasaki, Kenta Zhou, Qiliang Matsumoto, Yoshifumi Saiki, Takuro Moriyama, Masato Saijo, Yasuo Intern Med Case Report Two patients underwent hemodialysis. Case 1 with stage IV gastric cancer was treated with reduced doses of capecitabine (1,000 mg/m(2)/day, days 1 to 14) and oxaliplatin (65 mg/m(2), day 1). Although grade 1 thrombocytopenia occurred in the first cycle, grade 3 thrombocytopenia developed in the second cycle because of increasing dosage. After the dosage was reduced, chemotherapy was continued safely. Case 2 with stage IA gastroesophageal cancer was treated with radiotherapy followed by chemotherapy. Treatment with the same dose of CapeOX therapy as in case 1 resulted in no severe toxicity. We conclude that a half-dose of the CapeOX regimen is safe for gastric cancer patients undergoing hemodialysis. The Japanese Society of Internal Medicine 2019-06-27 2019-10-01 /pmc/articles/PMC6815905/ /pubmed/31243213 http://dx.doi.org/10.2169/internalmedicine.2718-19 Text en Copyright © 2019 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Sasaki, Kenta Zhou, Qiliang Matsumoto, Yoshifumi Saiki, Takuro Moriyama, Masato Saijo, Yasuo Treatment of Gastric and Gastroesophageal Cancer Patients with Hemodialysis by CapeOX |
title | Treatment of Gastric and Gastroesophageal Cancer Patients with Hemodialysis by CapeOX |
title_full | Treatment of Gastric and Gastroesophageal Cancer Patients with Hemodialysis by CapeOX |
title_fullStr | Treatment of Gastric and Gastroesophageal Cancer Patients with Hemodialysis by CapeOX |
title_full_unstemmed | Treatment of Gastric and Gastroesophageal Cancer Patients with Hemodialysis by CapeOX |
title_short | Treatment of Gastric and Gastroesophageal Cancer Patients with Hemodialysis by CapeOX |
title_sort | treatment of gastric and gastroesophageal cancer patients with hemodialysis by capeox |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815905/ https://www.ncbi.nlm.nih.gov/pubmed/31243213 http://dx.doi.org/10.2169/internalmedicine.2718-19 |
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