Cargando…

Treatment of Gastric and Gastroesophageal Cancer Patients with Hemodialysis by CapeOX

Two patients underwent hemodialysis. Case 1 with stage IV gastric cancer was treated with reduced doses of capecitabine (1,000 mg/m(2)/day, days 1 to 14) and oxaliplatin (65 mg/m(2), day 1). Although grade 1 thrombocytopenia occurred in the first cycle, grade 3 thrombocytopenia developed in the seco...

Descripción completa

Detalles Bibliográficos
Autores principales: Sasaki, Kenta, Zhou, Qiliang, Matsumoto, Yoshifumi, Saiki, Takuro, Moriyama, Masato, Saijo, Yasuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815905/
https://www.ncbi.nlm.nih.gov/pubmed/31243213
http://dx.doi.org/10.2169/internalmedicine.2718-19
_version_ 1783463281871028224
author Sasaki, Kenta
Zhou, Qiliang
Matsumoto, Yoshifumi
Saiki, Takuro
Moriyama, Masato
Saijo, Yasuo
author_facet Sasaki, Kenta
Zhou, Qiliang
Matsumoto, Yoshifumi
Saiki, Takuro
Moriyama, Masato
Saijo, Yasuo
author_sort Sasaki, Kenta
collection PubMed
description Two patients underwent hemodialysis. Case 1 with stage IV gastric cancer was treated with reduced doses of capecitabine (1,000 mg/m(2)/day, days 1 to 14) and oxaliplatin (65 mg/m(2), day 1). Although grade 1 thrombocytopenia occurred in the first cycle, grade 3 thrombocytopenia developed in the second cycle because of increasing dosage. After the dosage was reduced, chemotherapy was continued safely. Case 2 with stage IA gastroesophageal cancer was treated with radiotherapy followed by chemotherapy. Treatment with the same dose of CapeOX therapy as in case 1 resulted in no severe toxicity. We conclude that a half-dose of the CapeOX regimen is safe for gastric cancer patients undergoing hemodialysis.
format Online
Article
Text
id pubmed-6815905
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher The Japanese Society of Internal Medicine
record_format MEDLINE/PubMed
spelling pubmed-68159052019-10-29 Treatment of Gastric and Gastroesophageal Cancer Patients with Hemodialysis by CapeOX Sasaki, Kenta Zhou, Qiliang Matsumoto, Yoshifumi Saiki, Takuro Moriyama, Masato Saijo, Yasuo Intern Med Case Report Two patients underwent hemodialysis. Case 1 with stage IV gastric cancer was treated with reduced doses of capecitabine (1,000 mg/m(2)/day, days 1 to 14) and oxaliplatin (65 mg/m(2), day 1). Although grade 1 thrombocytopenia occurred in the first cycle, grade 3 thrombocytopenia developed in the second cycle because of increasing dosage. After the dosage was reduced, chemotherapy was continued safely. Case 2 with stage IA gastroesophageal cancer was treated with radiotherapy followed by chemotherapy. Treatment with the same dose of CapeOX therapy as in case 1 resulted in no severe toxicity. We conclude that a half-dose of the CapeOX regimen is safe for gastric cancer patients undergoing hemodialysis. The Japanese Society of Internal Medicine 2019-06-27 2019-10-01 /pmc/articles/PMC6815905/ /pubmed/31243213 http://dx.doi.org/10.2169/internalmedicine.2718-19 Text en Copyright © 2019 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Sasaki, Kenta
Zhou, Qiliang
Matsumoto, Yoshifumi
Saiki, Takuro
Moriyama, Masato
Saijo, Yasuo
Treatment of Gastric and Gastroesophageal Cancer Patients with Hemodialysis by CapeOX
title Treatment of Gastric and Gastroesophageal Cancer Patients with Hemodialysis by CapeOX
title_full Treatment of Gastric and Gastroesophageal Cancer Patients with Hemodialysis by CapeOX
title_fullStr Treatment of Gastric and Gastroesophageal Cancer Patients with Hemodialysis by CapeOX
title_full_unstemmed Treatment of Gastric and Gastroesophageal Cancer Patients with Hemodialysis by CapeOX
title_short Treatment of Gastric and Gastroesophageal Cancer Patients with Hemodialysis by CapeOX
title_sort treatment of gastric and gastroesophageal cancer patients with hemodialysis by capeox
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815905/
https://www.ncbi.nlm.nih.gov/pubmed/31243213
http://dx.doi.org/10.2169/internalmedicine.2718-19
work_keys_str_mv AT sasakikenta treatmentofgastricandgastroesophagealcancerpatientswithhemodialysisbycapeox
AT zhouqiliang treatmentofgastricandgastroesophagealcancerpatientswithhemodialysisbycapeox
AT matsumotoyoshifumi treatmentofgastricandgastroesophagealcancerpatientswithhemodialysisbycapeox
AT saikitakuro treatmentofgastricandgastroesophagealcancerpatientswithhemodialysisbycapeox
AT moriyamamasato treatmentofgastricandgastroesophagealcancerpatientswithhemodialysisbycapeox
AT saijoyasuo treatmentofgastricandgastroesophagealcancerpatientswithhemodialysisbycapeox