A Unique Case Of Tenofovir-Induced DRESS Syndrome Associated With Raynaud’s Of The Tongue

Drug reaction with eosinophilia and systemic symptoms (DRESS) is a potentially fatal severe adverse reaction to medications. Numerous drugs have been implicated, with carbamazepine and allopurinol being the most common. Tenofovir-induced DRESS is extremely rare. We report a case of a 65-year-old mal...

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Autores principales: Aqtash, Obadah, Ajmeri, Aman Naim, Thornhill, Brent A, Anderson, Elise, Carroll, Ryan, Elhamdani, Adee, Tackett, Eva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815911/
https://www.ncbi.nlm.nih.gov/pubmed/31695475
http://dx.doi.org/10.2147/IJGM.S215511
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author Aqtash, Obadah
Ajmeri, Aman Naim
Thornhill, Brent A
Anderson, Elise
Carroll, Ryan
Elhamdani, Adee
Tackett, Eva
author_facet Aqtash, Obadah
Ajmeri, Aman Naim
Thornhill, Brent A
Anderson, Elise
Carroll, Ryan
Elhamdani, Adee
Tackett, Eva
author_sort Aqtash, Obadah
collection PubMed
description Drug reaction with eosinophilia and systemic symptoms (DRESS) is a potentially fatal severe adverse reaction to medications. Numerous drugs have been implicated, with carbamazepine and allopurinol being the most common. Tenofovir-induced DRESS is extremely rare. We report a case of a 65-year-old male patient with a diffuse exfoliative maculopapular rash across his entire body of five weeks of duration. The patient also had icteric sclera, abnormal liver enzymes and Raynaud’s of the tongue, nose and the left fifth finger. After discontinuation of tenofovir, the case resolved over a span of ten days. A high index of suspicion is crucial along with the prompt withdrawal of the offending medication for a good outcome.
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spelling pubmed-68159112019-11-06 A Unique Case Of Tenofovir-Induced DRESS Syndrome Associated With Raynaud’s Of The Tongue Aqtash, Obadah Ajmeri, Aman Naim Thornhill, Brent A Anderson, Elise Carroll, Ryan Elhamdani, Adee Tackett, Eva Int J Gen Med Case Report Drug reaction with eosinophilia and systemic symptoms (DRESS) is a potentially fatal severe adverse reaction to medications. Numerous drugs have been implicated, with carbamazepine and allopurinol being the most common. Tenofovir-induced DRESS is extremely rare. We report a case of a 65-year-old male patient with a diffuse exfoliative maculopapular rash across his entire body of five weeks of duration. The patient also had icteric sclera, abnormal liver enzymes and Raynaud’s of the tongue, nose and the left fifth finger. After discontinuation of tenofovir, the case resolved over a span of ten days. A high index of suspicion is crucial along with the prompt withdrawal of the offending medication for a good outcome. Dove 2019-10-23 /pmc/articles/PMC6815911/ /pubmed/31695475 http://dx.doi.org/10.2147/IJGM.S215511 Text en © 2019 Aqtash et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Case Report
Aqtash, Obadah
Ajmeri, Aman Naim
Thornhill, Brent A
Anderson, Elise
Carroll, Ryan
Elhamdani, Adee
Tackett, Eva
A Unique Case Of Tenofovir-Induced DRESS Syndrome Associated With Raynaud’s Of The Tongue
title A Unique Case Of Tenofovir-Induced DRESS Syndrome Associated With Raynaud’s Of The Tongue
title_full A Unique Case Of Tenofovir-Induced DRESS Syndrome Associated With Raynaud’s Of The Tongue
title_fullStr A Unique Case Of Tenofovir-Induced DRESS Syndrome Associated With Raynaud’s Of The Tongue
title_full_unstemmed A Unique Case Of Tenofovir-Induced DRESS Syndrome Associated With Raynaud’s Of The Tongue
title_short A Unique Case Of Tenofovir-Induced DRESS Syndrome Associated With Raynaud’s Of The Tongue
title_sort unique case of tenofovir-induced dress syndrome associated with raynaud’s of the tongue
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815911/
https://www.ncbi.nlm.nih.gov/pubmed/31695475
http://dx.doi.org/10.2147/IJGM.S215511
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