Persistence of HIV reservoir following successful haematopoietic stem cell transplant for juvenile myelomonocytic leukaemia in a child with perinatally acquired HIV

This report describes a case of juvenile myelomonocytic leukaemia (JMML) on a background of both perinatally acquired HIV infection and congenital cytomegalovirus, and management of antiretroviral therapy during haematopoietic stem cell transplant. Peripheral blood HIV viral load remained below the...

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Detalles Bibliográficos
Autores principales: Dobson, G, Klein, N, Veys, P, Qasim, W, Silva, J, Cheng, IL, Shingadia, D, Tudor-Williams, G, Watters, SA, Lyall, H, Rao, A, Foster, C, Bamford, A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mediscript Ltd 2019
Materias:
Case Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6816122/
https://www.ncbi.nlm.nih.gov/pubmed/31700667
Descripción
Sumario:This report describes a case of juvenile myelomonocytic leukaemia (JMML) on a background of both perinatally acquired HIV infection and congenital cytomegalovirus, and management of antiretroviral therapy during haematopoietic stem cell transplant. Peripheral blood HIV viral load remained below the lower limit of detection throughout and following transplant and is currently <20 RNA copies/mL. The child is currently in remission from JMML, but HIV DNA remains detectable despite myeloablative conditioning and sustained plasma HIV viral suppression.

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