Phosphorylated TDP-43 aggregates in skeletal and cardiac muscle are a marker of myogenic degeneration in amyotrophic lateral sclerosis and various conditions

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is characterized pathologically by the occurrence of phosphorylated TDP-43 (pTDP-43)-immunoreactive neuronal and glial inclusions in the central nervous system. Recent studies have shown that pTDP-43 aggregates also occur in the skeletal muscles in a c...

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Detalles Bibliográficos
Autores principales: Mori, Fumiaki, Tada, Mari, Kon, Tomoya, Miki, Yasuo, Tanji, Kunikazu, Kurotaki, Hidekachi, Tomiyama, Masahiko, Ishihara, Tomohiko, Onodera, Osamu, Kakita, Akiyoshi, Wakabayashi, Koichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6816170/
https://www.ncbi.nlm.nih.gov/pubmed/31661037
http://dx.doi.org/10.1186/s40478-019-0824-1

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