NDP-MSH binding melanocortin-1 receptor ameliorates neuroinflammation and BBB disruption through CREB/Nr4a1/NF-κB pathway after intracerebral hemorrhage in mice

BACKGROUND: Neuroinflammation and blood-brain barrier (BBB) disruption are two vital mechanisms of secondary brain injury following intracerebral hemorrhage (ICH). Recently, melanocortin-1 receptor (Mc1r) activation by Nle4-D-Phe7-α-MSH (NDP-MSH) was shown to play a neuroprotective role in an experi...

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Detalles Bibliográficos
Autores principales: Wu, Xuan, Fu, Siming, Liu, Yun, Luo, Hansheng, Li, Feng, Wang, Yiying, Gao, Meng, Cheng, Yuan, Xie, Zongyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6816206/
https://www.ncbi.nlm.nih.gov/pubmed/31660977
http://dx.doi.org/10.1186/s12974-019-1591-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6816206/
https://www.ncbi.nlm.nih.gov/pubmed/31660977
http://dx.doi.org/10.1186/s12974-019-1591-4

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