Compartmentalized DNA repair: Rif1 S-acylation links DNA double-strand break repair to the nuclear membrane

DNA double-strand breaks (DSBs) disrupt the structural integrity of chromosomes. Proper DSB repair pathway choice is critical to avoid the type of gross chromosomal rearrangements that characterize cancer cells. Recent findings reveal S-fatty acylation and membrane anchorage of Rap1-interacting fact...

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Detalles Bibliográficos
Autores principales: Fontana, Gabriele A., Rass, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6816362/
https://www.ncbi.nlm.nih.gov/pubmed/31692850
http://dx.doi.org/10.1080/23723556.2019.1648025
Descripción
Sumario:DNA double-strand breaks (DSBs) disrupt the structural integrity of chromosomes. Proper DSB repair pathway choice is critical to avoid the type of gross chromosomal rearrangements that characterize cancer cells. Recent findings reveal S-fatty acylation and membrane anchorage of Rap1-interacting factor 1 (Rif1) as a mechanism providing spatial control over DSB repair pathway choice.

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