Compartmentalized DNA repair: Rif1 S-acylation links DNA double-strand break repair to the nuclear membrane

DNA double-strand breaks (DSBs) disrupt the structural integrity of chromosomes. Proper DSB repair pathway choice is critical to avoid the type of gross chromosomal rearrangements that characterize cancer cells. Recent findings reveal S-fatty acylation and membrane anchorage of Rap1-interacting fact...

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Autores principales: Fontana, Gabriele A., Rass, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Author’s Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6816362/
https://www.ncbi.nlm.nih.gov/pubmed/31692850
http://dx.doi.org/10.1080/23723556.2019.1648025
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author Fontana, Gabriele A.
Rass, Ulrich
author_facet Fontana, Gabriele A.
Rass, Ulrich
author_sort Fontana, Gabriele A.
collection PubMed
description DNA double-strand breaks (DSBs) disrupt the structural integrity of chromosomes. Proper DSB repair pathway choice is critical to avoid the type of gross chromosomal rearrangements that characterize cancer cells. Recent findings reveal S-fatty acylation and membrane anchorage of Rap1-interacting factor 1 (Rif1) as a mechanism providing spatial control over DSB repair pathway choice.
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spelling pubmed-68163622020-08-21 Compartmentalized DNA repair: Rif1 S-acylation links DNA double-strand break repair to the nuclear membrane Fontana, Gabriele A. Rass, Ulrich Mol Cell Oncol Author’s Views DNA double-strand breaks (DSBs) disrupt the structural integrity of chromosomes. Proper DSB repair pathway choice is critical to avoid the type of gross chromosomal rearrangements that characterize cancer cells. Recent findings reveal S-fatty acylation and membrane anchorage of Rap1-interacting factor 1 (Rif1) as a mechanism providing spatial control over DSB repair pathway choice. Taylor & Francis 2019-08-21 /pmc/articles/PMC6816362/ /pubmed/31692850 http://dx.doi.org/10.1080/23723556.2019.1648025 Text en © 2019 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author’s Views
Fontana, Gabriele A.
Rass, Ulrich
Compartmentalized DNA repair: Rif1 S-acylation links DNA double-strand break repair to the nuclear membrane
title Compartmentalized DNA repair: Rif1 S-acylation links DNA double-strand break repair to the nuclear membrane
title_full Compartmentalized DNA repair: Rif1 S-acylation links DNA double-strand break repair to the nuclear membrane
title_fullStr Compartmentalized DNA repair: Rif1 S-acylation links DNA double-strand break repair to the nuclear membrane
title_full_unstemmed Compartmentalized DNA repair: Rif1 S-acylation links DNA double-strand break repair to the nuclear membrane
title_short Compartmentalized DNA repair: Rif1 S-acylation links DNA double-strand break repair to the nuclear membrane
title_sort compartmentalized dna repair: rif1 s-acylation links dna double-strand break repair to the nuclear membrane
topic Author’s Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6816362/
https://www.ncbi.nlm.nih.gov/pubmed/31692850
http://dx.doi.org/10.1080/23723556.2019.1648025
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AT rassulrich compartmentalizeddnarepairrif1sacylationlinksdnadoublestrandbreakrepairtothenuclearmembrane

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