Telomere maintenance: regulating hTERC fate through RNA modifications

Disturbances in telomere maintenance are common in cancer. We recently showed that Single-strand-selective monofunctional uracil-DNA glycosylase 1 (SMUG1) promotes telomere homeostasis by regulating the stability of the telomeric RNA component (hTERC). SMUG1-mediated recognition of base modification...

Descripción completa

Detalles Bibliográficos
Autores principales: Lirussi, Lisa, Nilsen, Hilde
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Author’s Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6816388/
https://www.ncbi.nlm.nih.gov/pubmed/31692866
http://dx.doi.org/10.1080/23723556.2019.1670489
_version_ 1783463361771470848
author Lirussi, Lisa
Nilsen, Hilde
author_facet Lirussi, Lisa
Nilsen, Hilde
author_sort Lirussi, Lisa
collection PubMed
description Disturbances in telomere maintenance are common in cancer. We recently showed that Single-strand-selective monofunctional uracil-DNA glycosylase 1 (SMUG1) promotes telomere homeostasis by regulating the stability of the telomeric RNA component (hTERC). SMUG1-mediated recognition of base modifications may function in a regulated process serving to fine-tune the levels of hTERC.
format Online
Article
Text
id pubmed-6816388
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Taylor & Francis
record_format MEDLINE/PubMed
spelling pubmed-68163882020-09-28 Telomere maintenance: regulating hTERC fate through RNA modifications Lirussi, Lisa Nilsen, Hilde Mol Cell Oncol Author’s Views Disturbances in telomere maintenance are common in cancer. We recently showed that Single-strand-selective monofunctional uracil-DNA glycosylase 1 (SMUG1) promotes telomere homeostasis by regulating the stability of the telomeric RNA component (hTERC). SMUG1-mediated recognition of base modifications may function in a regulated process serving to fine-tune the levels of hTERC. Taylor & Francis 2019-10-15 /pmc/articles/PMC6816388/ /pubmed/31692866 http://dx.doi.org/10.1080/23723556.2019.1670489 Text en © 2019 The Author(s). Published with license by Taylor & Francis Group, LLC. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author’s Views
Lirussi, Lisa
Nilsen, Hilde
Telomere maintenance: regulating hTERC fate through RNA modifications
title Telomere maintenance: regulating hTERC fate through RNA modifications
title_full Telomere maintenance: regulating hTERC fate through RNA modifications
title_fullStr Telomere maintenance: regulating hTERC fate through RNA modifications
title_full_unstemmed Telomere maintenance: regulating hTERC fate through RNA modifications
title_short Telomere maintenance: regulating hTERC fate through RNA modifications
title_sort telomere maintenance: regulating hterc fate through rna modifications
topic Author’s Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6816388/
https://www.ncbi.nlm.nih.gov/pubmed/31692866
http://dx.doi.org/10.1080/23723556.2019.1670489
work_keys_str_mv AT lirussilisa telomeremaintenanceregulatinghtercfatethroughrnamodifications
AT nilsenhilde telomeremaintenanceregulatinghtercfatethroughrnamodifications

Ejemplares similares