Tumor suppression by control of matrix metalloproteinase recycling

Secretion of matrix metalloproteinases (MMPs) enables cancer cells to degrade extracellular matrix, thus promoting tumor invasion and metastasis. We have recently found that the endosomal protein WDFY2 serves as a gatekeeper for MMP recycling from endosomes and that deletion of WDFY2, which is frequ...

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Detalles Bibliográficos
Autores principales: Sneeggen, Marte, Schink, Kay O., Stenmark, Harald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6816391/
https://www.ncbi.nlm.nih.gov/pubmed/31692886
http://dx.doi.org/10.1080/23723556.2019.1646606
Descripción
Sumario:Secretion of matrix metalloproteinases (MMPs) enables cancer cells to degrade extracellular matrix, thus promoting tumor invasion and metastasis. We have recently found that the endosomal protein WDFY2 serves as a gatekeeper for MMP recycling from endosomes and that deletion of WDFY2, which is frequently lost in metastatic cancers, causes increased matrix degradation and cell invasion.

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