Another string to the polo bow: a new mitotic role of PLK1 in centromere protection

Polo-like kinase 1 (PLK1) plays a fundamental role in the spatiotemporal control of mitosis. Cells lacking PLK1 activity exhibit characteristic chromosome misalignment due to defects in microtubule-kinetochore organization and attachment. In our recently published paper, we uncover a new role for PL...

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Detalles Bibliográficos
Autores principales: Olukoga, Tomisin, Fernández-Casañas, María, Chan, Kok-Lung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Author’s Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6816413/
https://www.ncbi.nlm.nih.gov/pubmed/31692966
http://dx.doi.org/10.1080/23723556.2019.1658515
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author Olukoga, Tomisin
Fernández-Casañas, María
Chan, Kok-Lung
author_facet Olukoga, Tomisin
Fernández-Casañas, María
Chan, Kok-Lung
author_sort Olukoga, Tomisin
collection PubMed
description Polo-like kinase 1 (PLK1) plays a fundamental role in the spatiotemporal control of mitosis. Cells lacking PLK1 activity exhibit characteristic chromosome misalignment due to defects in microtubule-kinetochore organization and attachment. In our recently published paper, we uncover a new role for PLK1 in the preservation and maintenance of centromere integrity.
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spelling pubmed-68164132020-09-17 Another string to the polo bow: a new mitotic role of PLK1 in centromere protection Olukoga, Tomisin Fernández-Casañas, María Chan, Kok-Lung Mol Cell Oncol Author’s Views Polo-like kinase 1 (PLK1) plays a fundamental role in the spatiotemporal control of mitosis. Cells lacking PLK1 activity exhibit characteristic chromosome misalignment due to defects in microtubule-kinetochore organization and attachment. In our recently published paper, we uncover a new role for PLK1 in the preservation and maintenance of centromere integrity. Taylor & Francis 2019-09-17 /pmc/articles/PMC6816413/ /pubmed/31692966 http://dx.doi.org/10.1080/23723556.2019.1658515 Text en © 2019 The Author(s). Published with license by Taylor & Francis Group, LLC. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Author’s Views
Olukoga, Tomisin
Fernández-Casañas, María
Chan, Kok-Lung
Another string to the polo bow: a new mitotic role of PLK1 in centromere protection
title Another string to the polo bow: a new mitotic role of PLK1 in centromere protection
title_full Another string to the polo bow: a new mitotic role of PLK1 in centromere protection
title_fullStr Another string to the polo bow: a new mitotic role of PLK1 in centromere protection
title_full_unstemmed Another string to the polo bow: a new mitotic role of PLK1 in centromere protection
title_short Another string to the polo bow: a new mitotic role of PLK1 in centromere protection
title_sort another string to the polo bow: a new mitotic role of plk1 in centromere protection
topic Author’s Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6816413/
https://www.ncbi.nlm.nih.gov/pubmed/31692966
http://dx.doi.org/10.1080/23723556.2019.1658515
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