BRCA1-BARD1: the importance of being in shape

The breast cancer type-1 susceptibility protein (BRCA1) contributes to genome integrity through homologous recombinational DNA repair and by protecting stalled replication forks from nucleolytic degradation. We recently discovered that fork protection requires a conformational change of BRCA1 unimpo...

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Detalles Bibliográficos
Autores principales: Daza-Martin, Manuel, Densham, Ruth M., Morris, Joanna R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Author’s Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6816425/
https://www.ncbi.nlm.nih.gov/pubmed/31692900
http://dx.doi.org/10.1080/23723556.2019.1656500
Descripción
Sumario:The breast cancer type-1 susceptibility protein (BRCA1) contributes to genome integrity through homologous recombinational DNA repair and by protecting stalled replication forks from nucleolytic degradation. We recently discovered that fork protection requires a conformational change of BRCA1 unimportant to homologous recombination repair, indicating separate roles for BRCA1 in these pathways.

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