BRCA1-BARD1: the importance of being in shape

The breast cancer type-1 susceptibility protein (BRCA1) contributes to genome integrity through homologous recombinational DNA repair and by protecting stalled replication forks from nucleolytic degradation. We recently discovered that fork protection requires a conformational change of BRCA1 unimpo...

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Detalles Bibliográficos
Autores principales: Daza-Martin, Manuel, Densham, Ruth M., Morris, Joanna R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Author’s Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6816425/
https://www.ncbi.nlm.nih.gov/pubmed/31692900
http://dx.doi.org/10.1080/23723556.2019.1656500
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author Daza-Martin, Manuel
Densham, Ruth M.
Morris, Joanna R.
author_facet Daza-Martin, Manuel
Densham, Ruth M.
Morris, Joanna R.
author_sort Daza-Martin, Manuel
collection PubMed
description The breast cancer type-1 susceptibility protein (BRCA1) contributes to genome integrity through homologous recombinational DNA repair and by protecting stalled replication forks from nucleolytic degradation. We recently discovered that fork protection requires a conformational change of BRCA1 unimportant to homologous recombination repair, indicating separate roles for BRCA1 in these pathways.
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spelling pubmed-68164252020-09-11 BRCA1-BARD1: the importance of being in shape Daza-Martin, Manuel Densham, Ruth M. Morris, Joanna R. Mol Cell Oncol Author’s Views The breast cancer type-1 susceptibility protein (BRCA1) contributes to genome integrity through homologous recombinational DNA repair and by protecting stalled replication forks from nucleolytic degradation. We recently discovered that fork protection requires a conformational change of BRCA1 unimportant to homologous recombination repair, indicating separate roles for BRCA1 in these pathways. Taylor & Francis 2019-09-11 /pmc/articles/PMC6816425/ /pubmed/31692900 http://dx.doi.org/10.1080/23723556.2019.1656500 Text en © 2019 The Author(s). Published with license by Taylor & Francis Group, LLC. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Author’s Views
Daza-Martin, Manuel
Densham, Ruth M.
Morris, Joanna R.
BRCA1-BARD1: the importance of being in shape
title BRCA1-BARD1: the importance of being in shape
title_full BRCA1-BARD1: the importance of being in shape
title_fullStr BRCA1-BARD1: the importance of being in shape
title_full_unstemmed BRCA1-BARD1: the importance of being in shape
title_short BRCA1-BARD1: the importance of being in shape
title_sort brca1-bard1: the importance of being in shape
topic Author’s Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6816425/
https://www.ncbi.nlm.nih.gov/pubmed/31692900
http://dx.doi.org/10.1080/23723556.2019.1656500
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