Chromatin regulation at the intersection of estrogen receptor and PI3K pathways in breast cancer

Estrogen Receptor (ER) and the phosphoinositide 3-kinase (PI3K) pathways participate in regulatory crosstalk in breast cancer. We identified that chromatin regulation is at the intersection of oncogenic PI3K and ER. The PI3K effectors AKT, also known as protein kinase B (PKB), and SGK (serum/glucoco...

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Detalles Bibliográficos
Autores principales: Castel, Pau, Toska, Eneda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Author’s Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6816426/
https://www.ncbi.nlm.nih.gov/pubmed/31692833
http://dx.doi.org/10.1080/23723556.2019.1625620
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author Castel, Pau
Toska, Eneda
author_facet Castel, Pau
Toska, Eneda
author_sort Castel, Pau
collection PubMed
description Estrogen Receptor (ER) and the phosphoinositide 3-kinase (PI3K) pathways participate in regulatory crosstalk in breast cancer. We identified that chromatin regulation is at the intersection of oncogenic PI3K and ER. The PI3K effectors AKT, also known as protein kinase B (PKB), and SGK (serum/glucocorticoid-regulated kinase) play a redundant role by phosphorylating the chromatin regulator KMT2D and modulating ER activity and therapy resistance.
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spelling pubmed-68164262020-09-02 Chromatin regulation at the intersection of estrogen receptor and PI3K pathways in breast cancer Castel, Pau Toska, Eneda Mol Cell Oncol Author’s Views Estrogen Receptor (ER) and the phosphoinositide 3-kinase (PI3K) pathways participate in regulatory crosstalk in breast cancer. We identified that chromatin regulation is at the intersection of oncogenic PI3K and ER. The PI3K effectors AKT, also known as protein kinase B (PKB), and SGK (serum/glucocorticoid-regulated kinase) play a redundant role by phosphorylating the chromatin regulator KMT2D and modulating ER activity and therapy resistance. Taylor & Francis 2019-09-02 /pmc/articles/PMC6816426/ /pubmed/31692833 http://dx.doi.org/10.1080/23723556.2019.1625620 Text en © 2019 The Author(s). Published with license by Taylor & Francis Group, LLC. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author’s Views
Castel, Pau
Toska, Eneda
Chromatin regulation at the intersection of estrogen receptor and PI3K pathways in breast cancer
title Chromatin regulation at the intersection of estrogen receptor and PI3K pathways in breast cancer
title_full Chromatin regulation at the intersection of estrogen receptor and PI3K pathways in breast cancer
title_fullStr Chromatin regulation at the intersection of estrogen receptor and PI3K pathways in breast cancer
title_full_unstemmed Chromatin regulation at the intersection of estrogen receptor and PI3K pathways in breast cancer
title_short Chromatin regulation at the intersection of estrogen receptor and PI3K pathways in breast cancer
title_sort chromatin regulation at the intersection of estrogen receptor and pi3k pathways in breast cancer
topic Author’s Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6816426/
https://www.ncbi.nlm.nih.gov/pubmed/31692833
http://dx.doi.org/10.1080/23723556.2019.1625620
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