Identification and characterization of an IgG sequence variant with an 11 kDa heavy chain C-terminal extension using a combination of mass spectrometry and high-throughput sequencing analysis

Protein primary structure is a potential critical quality attribute for biotherapeutics. Identifying and characterizing any sequence variants present is essential for product development. A sequence variant ~11 kDa larger than the expected IgG mass was observed by size-exclusion chromatography and t...

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Detalles Bibliográficos
Autores principales: Harris, Claire, Xu, Weichen, Grassi, Luigi, Wang, Chunlei, Markle, Abigail, Hardman, Colin, Stevens, Richard, Miro-Quesada, Guillermo, Hatton, Diane, Wang, Jihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6816433/
https://www.ncbi.nlm.nih.gov/pubmed/31570042
http://dx.doi.org/10.1080/19420862.2019.1667740

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