Beyond apical ballooning: computational modelling reveals morphological features of Takotsubo cardiomyopathy

Takotsubo cardiomyopathy (TCM) is characterized by transient myocardial dysfunction, typically at the left ventricular (LV) apex. Its pathophysiology and recovery mechanisms remain unknown. We investigated LV morphology and deformation in n = 28 TCM patients. Patients with MRI within 5 days from adm...

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Autores principales: Pontecorboli, Giulia, Biglino, Giovanni, Milano, Elena Giulia, Sophocleous, Froso, Biffi, Benedetta, Dastidar, Amardeep Ghosh, Schievano, Silvia, Di Mario, Carlo, Bucciarelli-Ducci, Chiara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6816475/
https://www.ncbi.nlm.nih.gov/pubmed/31269802
http://dx.doi.org/10.1080/10255842.2019.1632836
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author Pontecorboli, Giulia
Biglino, Giovanni
Milano, Elena Giulia
Sophocleous, Froso
Biffi, Benedetta
Dastidar, Amardeep Ghosh
Schievano, Silvia
Di Mario, Carlo
Bucciarelli-Ducci, Chiara
author_facet Pontecorboli, Giulia
Biglino, Giovanni
Milano, Elena Giulia
Sophocleous, Froso
Biffi, Benedetta
Dastidar, Amardeep Ghosh
Schievano, Silvia
Di Mario, Carlo
Bucciarelli-Ducci, Chiara
author_sort Pontecorboli, Giulia
collection PubMed
description Takotsubo cardiomyopathy (TCM) is characterized by transient myocardial dysfunction, typically at the left ventricular (LV) apex. Its pathophysiology and recovery mechanisms remain unknown. We investigated LV morphology and deformation in n = 28 TCM patients. Patients with MRI within 5 days from admission (“early TCM”) showed reduced LVEF and higher ventricular volumes, but no differences in ECG, global strains or myocardial oedema. Statistical shape modelling described LV size (Mode 1), apical sphericity (Mode 2) and height (Mode 3). Significant differences in Mode 1 suggest that “early TCM” LV remodeling is mainly influenced by a change in ventricular size rather than apical sphericity.
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spelling pubmed-68164752019-11-07 Beyond apical ballooning: computational modelling reveals morphological features of Takotsubo cardiomyopathy Pontecorboli, Giulia Biglino, Giovanni Milano, Elena Giulia Sophocleous, Froso Biffi, Benedetta Dastidar, Amardeep Ghosh Schievano, Silvia Di Mario, Carlo Bucciarelli-Ducci, Chiara Comput Methods Biomech Biomed Engin Article Takotsubo cardiomyopathy (TCM) is characterized by transient myocardial dysfunction, typically at the left ventricular (LV) apex. Its pathophysiology and recovery mechanisms remain unknown. We investigated LV morphology and deformation in n = 28 TCM patients. Patients with MRI within 5 days from admission (“early TCM”) showed reduced LVEF and higher ventricular volumes, but no differences in ECG, global strains or myocardial oedema. Statistical shape modelling described LV size (Mode 1), apical sphericity (Mode 2) and height (Mode 3). Significant differences in Mode 1 suggest that “early TCM” LV remodeling is mainly influenced by a change in ventricular size rather than apical sphericity. Taylor & Francis 2019-07-03 /pmc/articles/PMC6816475/ /pubmed/31269802 http://dx.doi.org/10.1080/10255842.2019.1632836 Text en © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
Pontecorboli, Giulia
Biglino, Giovanni
Milano, Elena Giulia
Sophocleous, Froso
Biffi, Benedetta
Dastidar, Amardeep Ghosh
Schievano, Silvia
Di Mario, Carlo
Bucciarelli-Ducci, Chiara
Beyond apical ballooning: computational modelling reveals morphological features of Takotsubo cardiomyopathy
title Beyond apical ballooning: computational modelling reveals morphological features of Takotsubo cardiomyopathy
title_full Beyond apical ballooning: computational modelling reveals morphological features of Takotsubo cardiomyopathy
title_fullStr Beyond apical ballooning: computational modelling reveals morphological features of Takotsubo cardiomyopathy
title_full_unstemmed Beyond apical ballooning: computational modelling reveals morphological features of Takotsubo cardiomyopathy
title_short Beyond apical ballooning: computational modelling reveals morphological features of Takotsubo cardiomyopathy
title_sort beyond apical ballooning: computational modelling reveals morphological features of takotsubo cardiomyopathy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6816475/
https://www.ncbi.nlm.nih.gov/pubmed/31269802
http://dx.doi.org/10.1080/10255842.2019.1632836
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