Drug-induced Reduction of Gamma Carboxylation in Osteocalcin: What is the Fallback?

Osteoporosis is a medical condition in which bone becomes fragile and weak. In this condition, the quality and density of the bone are reduced. Vitamin K is vital for bone mineralization as it plays a vital role in the gamma-carboxylation of osteocalcin. Therefore, if there is a deficiency of vitami...

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Autores principales: Usman, Norina, Qaseem, Aisha, Jayaraj, Joseph S, Fathima, Nida, Janapala, Rajesh Naidu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2019
Materias:
Orthopedics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6816527/
https://www.ncbi.nlm.nih.gov/pubmed/31667038
http://dx.doi.org/10.7759/cureus.5504
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author Usman, Norina
Qaseem, Aisha
Jayaraj, Joseph S
Fathima, Nida
Janapala, Rajesh Naidu
author_facet Usman, Norina
Qaseem, Aisha
Jayaraj, Joseph S
Fathima, Nida
Janapala, Rajesh Naidu
author_sort Usman, Norina
collection PubMed
description Osteoporosis is a medical condition in which bone becomes fragile and weak. In this condition, the quality and density of the bone are reduced. Vitamin K is vital for bone mineralization as it plays a vital role in the gamma-carboxylation of osteocalcin. Therefore, if there is a deficiency of vitamin K, it can lead to osteoporosis due to undercarboxylated osteocalcin. Warfarin is the most widely used anticoagulant in the elderly. In this article, we reviewed how Warfarin, an inhibitor of vitamin K, affects bone remodeling and leads to osteoporosis
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spelling pubmed-68165272019-10-30 Drug-induced Reduction of Gamma Carboxylation in Osteocalcin: What is the Fallback? Usman, Norina Qaseem, Aisha Jayaraj, Joseph S Fathima, Nida Janapala, Rajesh Naidu Cureus Orthopedics Osteoporosis is a medical condition in which bone becomes fragile and weak. In this condition, the quality and density of the bone are reduced. Vitamin K is vital for bone mineralization as it plays a vital role in the gamma-carboxylation of osteocalcin. Therefore, if there is a deficiency of vitamin K, it can lead to osteoporosis due to undercarboxylated osteocalcin. Warfarin is the most widely used anticoagulant in the elderly. In this article, we reviewed how Warfarin, an inhibitor of vitamin K, affects bone remodeling and leads to osteoporosis Cureus 2019-08-28 /pmc/articles/PMC6816527/ /pubmed/31667038 http://dx.doi.org/10.7759/cureus.5504 Text en Copyright © 2019, Usman et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Orthopedics
Usman, Norina
Qaseem, Aisha
Jayaraj, Joseph S
Fathima, Nida
Janapala, Rajesh Naidu
Drug-induced Reduction of Gamma Carboxylation in Osteocalcin: What is the Fallback?
title Drug-induced Reduction of Gamma Carboxylation in Osteocalcin: What is the Fallback?
title_full Drug-induced Reduction of Gamma Carboxylation in Osteocalcin: What is the Fallback?
title_fullStr Drug-induced Reduction of Gamma Carboxylation in Osteocalcin: What is the Fallback?
title_full_unstemmed Drug-induced Reduction of Gamma Carboxylation in Osteocalcin: What is the Fallback?
title_short Drug-induced Reduction of Gamma Carboxylation in Osteocalcin: What is the Fallback?
title_sort drug-induced reduction of gamma carboxylation in osteocalcin: what is the fallback?
topic Orthopedics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6816527/
https://www.ncbi.nlm.nih.gov/pubmed/31667038
http://dx.doi.org/10.7759/cureus.5504
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