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Computational design and interpretation of single-RNA translation experiments

Advances in fluorescence microscopy have introduced new assays to quantify live-cell translation dynamics at single-RNA resolution. We introduce a detailed, yet efficient sequence-based stochastic model that generates realistic synthetic data for several such assays, including Fluorescence Correlati...

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Detalles Bibliográficos
Autores principales:	Aguilera, Luis U., Raymond, William, Fox, Zachary R., May, Michael, Djokic, Elliot, Morisaki, Tatsuya, Stasevich, Timothy J., Munsky, Brian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6816579/ https://www.ncbi.nlm.nih.gov/pubmed/31618265 http://dx.doi.org/10.1371/journal.pcbi.1007425

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