Cargando…
免疫检查点抑制剂相关血液毒性处理的临床诊疗建议
Immune checkpoint inhibitors are able to reactivate the immune system therefore enhance the anti-tumor effects. However, over-activated T cells may induce immune related adverse events (irAEs). Hematological irAEs are rarely reported, which mainly represent as mono-lineage cytopenia or pancytopenia,...
| Formato: | Online Artículo Texto |
|---|---|
| Lenguaje: | English |
| Publicado: |
中国肺癌杂志编辑部
2019
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6817424/ https://www.ncbi.nlm.nih.gov/pubmed/31650953 http://dx.doi.org/10.3779/j.issn.1009-3419.2019.10.13 |
| _version_ | 1783463415063248896 |
|---|---|
| collection | PubMed |
| description | Immune checkpoint inhibitors are able to reactivate the immune system therefore enhance the anti-tumor effects. However, over-activated T cells may induce immune related adverse events (irAEs). Hematological irAEs are rarely reported, which mainly represent as mono-lineage cytopenia or pancytopenia, including autoimmune hemolytic anemia (AIHA), immune thrombocytopenia (ITP), neutropenia and aplastic anemia, sometimes even lethal, such as hemophagocytic lymphohistiocytosis. The clinical manifestations of hematological irAEs will be summarized and recommendations of diagnosis and treatment are proposed. |
| format | Online Article Text |
| id | pubmed-6817424 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| publisher | 中国肺癌杂志编辑部 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-68174242019-11-12 免疫检查点抑制剂相关血液毒性处理的临床诊疗建议 Zhongguo Fei Ai Za Zhi 免疫检查点抑制剂专题 Immune checkpoint inhibitors are able to reactivate the immune system therefore enhance the anti-tumor effects. However, over-activated T cells may induce immune related adverse events (irAEs). Hematological irAEs are rarely reported, which mainly represent as mono-lineage cytopenia or pancytopenia, including autoimmune hemolytic anemia (AIHA), immune thrombocytopenia (ITP), neutropenia and aplastic anemia, sometimes even lethal, such as hemophagocytic lymphohistiocytosis. The clinical manifestations of hematological irAEs will be summarized and recommendations of diagnosis and treatment are proposed. 中国肺癌杂志编辑部 2019-10-20 /pmc/articles/PMC6817424/ /pubmed/31650953 http://dx.doi.org/10.3779/j.issn.1009-3419.2019.10.13 Text en 版权所有©《中国肺癌杂志》编辑部2019 https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 3.0) License. See: https://creativecommons.org/licenses/by/3.0/ |
| spellingShingle | 免疫检查点抑制剂专题 免疫检查点抑制剂相关血液毒性处理的临床诊疗建议 |
| title | 免疫检查点抑制剂相关血液毒性处理的临床诊疗建议 |
| title_full | 免疫检查点抑制剂相关血液毒性处理的临床诊疗建议 |
| title_fullStr | 免疫检查点抑制剂相关血液毒性处理的临床诊疗建议 |
| title_full_unstemmed | 免疫检查点抑制剂相关血液毒性处理的临床诊疗建议 |
| title_short | 免疫检查点抑制剂相关血液毒性处理的临床诊疗建议 |
| title_sort | 免疫检查点抑制剂相关血液毒性处理的临床诊疗建议 |
| topic | 免疫检查点抑制剂专题 |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6817424/ https://www.ncbi.nlm.nih.gov/pubmed/31650953 http://dx.doi.org/10.3779/j.issn.1009-3419.2019.10.13 |
| work_keys_str_mv | AT miǎnyìjiǎnchádiǎnyìzhìjìxiāngguānxuèyèdúxìngchùlǐdelínchuángzhěnliáojiànyì AT miǎnyìjiǎnchádiǎnyìzhìjìxiāngguānxuèyèdúxìngchùlǐdelínchuángzhěnliáojiànyì AT miǎnyìjiǎnchádiǎnyìzhìjìxiāngguānxuèyèdúxìngchùlǐdelínchuángzhěnliáojiànyì AT miǎnyìjiǎnchádiǎnyìzhìjìxiāngguānxuèyèdúxìngchùlǐdelínchuángzhěnliáojiànyì AT miǎnyìjiǎnchádiǎnyìzhìjìxiāngguānxuèyèdúxìngchùlǐdelínchuángzhěnliáojiànyì AT miǎnyìjiǎnchádiǎnyìzhìjìxiāngguānxuèyèdúxìngchùlǐdelínchuángzhěnliáojiànyì AT miǎnyìjiǎnchádiǎnyìzhìjìxiāngguānxuèyèdúxìngchùlǐdelínchuángzhěnliáojiànyì AT miǎnyìjiǎnchádiǎnyìzhìjìxiāngguānxuèyèdúxìngchùlǐdelínchuángzhěnliáojiànyì AT miǎnyìjiǎnchádiǎnyìzhìjìxiāngguānxuèyèdúxìngchùlǐdelínchuángzhěnliáojiànyì AT miǎnyìjiǎnchádiǎnyìzhìjìxiāngguānxuèyèdúxìngchùlǐdelínchuángzhěnliáojiànyì AT miǎnyìjiǎnchádiǎnyìzhìjìxiāngguānxuèyèdúxìngchùlǐdelínchuángzhěnliáojiànyì AT miǎnyìjiǎnchádiǎnyìzhìjìxiāngguānxuèyèdúxìngchùlǐdelínchuángzhěnliáojiànyì AT miǎnyìjiǎnchádiǎnyìzhìjìxiāngguānxuèyèdúxìngchùlǐdelínchuángzhěnliáojiànyì |