cis Elements that Mediate RNA Polymerase II Pausing Regulate Human Gene Expression

Aberrant gene expression underlies many human diseases. RNA polymerase II (Pol II) pausing is a key regulatory step in transcription. Here, we mapped the locations of RNA Pol II in normal human cells and found that RNA Pol II pauses in a consistent manner across individuals and cell types. At more t...

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Detalles Bibliográficos
Autores principales: Watts, Jason A., Burdick, Joshua, Daigneault, Jillian, Zhu, Zhengwei, Grunseich, Christopher, Bruzel, Alan, Cheung, Vivian G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6817524/
https://www.ncbi.nlm.nih.gov/pubmed/31495490
http://dx.doi.org/10.1016/j.ajhg.2019.08.003

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