Cargando…
Efficacy and Tolerance of Intensity Modulated Radiation Therapy for Skull Base Meningioma
PURPOSE: The purpose of this study was to evaluate the efficacy and tolerance of normofractionated stereotactic radiation therapy (RT) and intensity modulated RT with helical tomotherapy for skull base meningioma. METHODS AND MATERIALS: Between January 2009 and 2014, 46 patients with skull base meni...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6817551/ https://www.ncbi.nlm.nih.gov/pubmed/31673652 http://dx.doi.org/10.1016/j.adro.2019.07.009 |
_version_ | 1783463444635189248 |
---|---|
author | Brahimi, Youssef Antoni, Delphine Srour, Robin Proust, François Thiery, Alicia Wagner, Pierre Noel, Georges |
author_facet | Brahimi, Youssef Antoni, Delphine Srour, Robin Proust, François Thiery, Alicia Wagner, Pierre Noel, Georges |
author_sort | Brahimi, Youssef |
collection | PubMed |
description | PURPOSE: The purpose of this study was to evaluate the efficacy and tolerance of normofractionated stereotactic radiation therapy (RT) and intensity modulated RT with helical tomotherapy for skull base meningioma. METHODS AND MATERIALS: Between January 2009 and 2014, 46 patients with skull base meningioma were treated with normofractionated intensity modulated RT in stereotactic conditions (50%) or with helical tomotherapy (50%). Most of the lesions were localized in the cavernous sinus (59%). The mean planning target volume was 47.2 mL (range, 1.1-223 mL). RESULTS: After treatment, 5 lesions exhibited a partial response radiologically and 39 lesions were stable. At the time of treatment, 35 patients were symptomatic with a mean of 2 symptoms per patient. The most frequent symptoms were visual impairment (41%), cranial nerve dysfunction (20%), and headache (16%). The median follow-up time was 42 months (range, 10-76 months). After RT, 71% of patients exhibited an improvement of at least 1 symptom with a median interval of 15.6 months (range, 5.3-30.5 months). The most frequent improved symptoms were cranial nerve deficits (47%), visual impairment (45%), and headache (42%).The clinical response was correlated with the clinical target volume (CTV) margin (P = .06), extended clinical follow-up time (P = .004), and larger planning target volume (P = .05) by univariate analysis. Taking in account correlation factors, in the multivariate analysis, only CTV was a favorable significant factor of clinical improvement (P = .049; hazard ratio: 5 95%; confidence interval, 1.1-28). We observed 3 cases of trigeminal nerve dysfunction at 4.2, 5.7, and 24.6 months; 2 cases of visual disturbance at 10.1 and 24 months; 2 cases of neurocognitive disorders at 12.9 and 35.2 months; and 1 case of stroke at 20.3 months. CONCLUSIONS: RT for skull base meningiomas is an effective and safe treatment, leading in most cases to clinical improvement. The addition of a CTV margin to meningioma volume improved the symptoms of patients. |
format | Online Article Text |
id | pubmed-6817551 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-68175512019-10-31 Efficacy and Tolerance of Intensity Modulated Radiation Therapy for Skull Base Meningioma Brahimi, Youssef Antoni, Delphine Srour, Robin Proust, François Thiery, Alicia Wagner, Pierre Noel, Georges Adv Radiat Oncol Central Nervous System PURPOSE: The purpose of this study was to evaluate the efficacy and tolerance of normofractionated stereotactic radiation therapy (RT) and intensity modulated RT with helical tomotherapy for skull base meningioma. METHODS AND MATERIALS: Between January 2009 and 2014, 46 patients with skull base meningioma were treated with normofractionated intensity modulated RT in stereotactic conditions (50%) or with helical tomotherapy (50%). Most of the lesions were localized in the cavernous sinus (59%). The mean planning target volume was 47.2 mL (range, 1.1-223 mL). RESULTS: After treatment, 5 lesions exhibited a partial response radiologically and 39 lesions were stable. At the time of treatment, 35 patients were symptomatic with a mean of 2 symptoms per patient. The most frequent symptoms were visual impairment (41%), cranial nerve dysfunction (20%), and headache (16%). The median follow-up time was 42 months (range, 10-76 months). After RT, 71% of patients exhibited an improvement of at least 1 symptom with a median interval of 15.6 months (range, 5.3-30.5 months). The most frequent improved symptoms were cranial nerve deficits (47%), visual impairment (45%), and headache (42%).The clinical response was correlated with the clinical target volume (CTV) margin (P = .06), extended clinical follow-up time (P = .004), and larger planning target volume (P = .05) by univariate analysis. Taking in account correlation factors, in the multivariate analysis, only CTV was a favorable significant factor of clinical improvement (P = .049; hazard ratio: 5 95%; confidence interval, 1.1-28). We observed 3 cases of trigeminal nerve dysfunction at 4.2, 5.7, and 24.6 months; 2 cases of visual disturbance at 10.1 and 24 months; 2 cases of neurocognitive disorders at 12.9 and 35.2 months; and 1 case of stroke at 20.3 months. CONCLUSIONS: RT for skull base meningiomas is an effective and safe treatment, leading in most cases to clinical improvement. The addition of a CTV margin to meningioma volume improved the symptoms of patients. Elsevier 2019-07-23 /pmc/articles/PMC6817551/ /pubmed/31673652 http://dx.doi.org/10.1016/j.adro.2019.07.009 Text en © 2019 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Central Nervous System Brahimi, Youssef Antoni, Delphine Srour, Robin Proust, François Thiery, Alicia Wagner, Pierre Noel, Georges Efficacy and Tolerance of Intensity Modulated Radiation Therapy for Skull Base Meningioma |
title | Efficacy and Tolerance of Intensity Modulated Radiation Therapy for Skull Base Meningioma |
title_full | Efficacy and Tolerance of Intensity Modulated Radiation Therapy for Skull Base Meningioma |
title_fullStr | Efficacy and Tolerance of Intensity Modulated Radiation Therapy for Skull Base Meningioma |
title_full_unstemmed | Efficacy and Tolerance of Intensity Modulated Radiation Therapy for Skull Base Meningioma |
title_short | Efficacy and Tolerance of Intensity Modulated Radiation Therapy for Skull Base Meningioma |
title_sort | efficacy and tolerance of intensity modulated radiation therapy for skull base meningioma |
topic | Central Nervous System |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6817551/ https://www.ncbi.nlm.nih.gov/pubmed/31673652 http://dx.doi.org/10.1016/j.adro.2019.07.009 |
work_keys_str_mv | AT brahimiyoussef efficacyandtoleranceofintensitymodulatedradiationtherapyforskullbasemeningioma AT antonidelphine efficacyandtoleranceofintensitymodulatedradiationtherapyforskullbasemeningioma AT srourrobin efficacyandtoleranceofintensitymodulatedradiationtherapyforskullbasemeningioma AT proustfrancois efficacyandtoleranceofintensitymodulatedradiationtherapyforskullbasemeningioma AT thieryalicia efficacyandtoleranceofintensitymodulatedradiationtherapyforskullbasemeningioma AT wagnerpierre efficacyandtoleranceofintensitymodulatedradiationtherapyforskullbasemeningioma AT noelgeorges efficacyandtoleranceofintensitymodulatedradiationtherapyforskullbasemeningioma |