The Role of TLRs in Anti-cancer Immunity and Tumor Rejection

In recent years, a lot of scientific interest has focused on cancer immunotherapy. Although chronic inflammation has been described as one of the hallmarks of cancer, acute inflammation can actually trigger the immune system to fight diseases, including cancer. Toll-like receptor (TLR) ligands have...

Descripción completa

Detalles Bibliográficos
Autores principales: Urban-Wojciuk, Zuzanna, Khan, Mohd M., Oyler, Benjamin L., Fåhraeus, Robin, Marek-Trzonkowska, Natalia, Nita-Lazar, Aleksandra, Hupp, Ted R., Goodlett, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6817561/
https://www.ncbi.nlm.nih.gov/pubmed/31695691
http://dx.doi.org/10.3389/fimmu.2019.02388
_version_ 1783463445840003072
author Urban-Wojciuk, Zuzanna
Khan, Mohd M.
Oyler, Benjamin L.
Fåhraeus, Robin
Marek-Trzonkowska, Natalia
Nita-Lazar, Aleksandra
Hupp, Ted R.
Goodlett, David R.
author_facet Urban-Wojciuk, Zuzanna
Khan, Mohd M.
Oyler, Benjamin L.
Fåhraeus, Robin
Marek-Trzonkowska, Natalia
Nita-Lazar, Aleksandra
Hupp, Ted R.
Goodlett, David R.
author_sort Urban-Wojciuk, Zuzanna
collection PubMed
description In recent years, a lot of scientific interest has focused on cancer immunotherapy. Although chronic inflammation has been described as one of the hallmarks of cancer, acute inflammation can actually trigger the immune system to fight diseases, including cancer. Toll-like receptor (TLR) ligands have long been used as adjuvants for traditional vaccines and it seems they may also play a role enhancing efficiency of tumor immunotherapy. The aim of this perspective is to discuss the effects of TLR stimulation in cancer, expression of various TLRs in different types of tumors, and finally the role of TLRs in anti-cancer immunity and tumor rejection.
format Online
Article
Text
id pubmed-6817561
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-68175612019-11-06 The Role of TLRs in Anti-cancer Immunity and Tumor Rejection Urban-Wojciuk, Zuzanna Khan, Mohd M. Oyler, Benjamin L. Fåhraeus, Robin Marek-Trzonkowska, Natalia Nita-Lazar, Aleksandra Hupp, Ted R. Goodlett, David R. Front Immunol Immunology In recent years, a lot of scientific interest has focused on cancer immunotherapy. Although chronic inflammation has been described as one of the hallmarks of cancer, acute inflammation can actually trigger the immune system to fight diseases, including cancer. Toll-like receptor (TLR) ligands have long been used as adjuvants for traditional vaccines and it seems they may also play a role enhancing efficiency of tumor immunotherapy. The aim of this perspective is to discuss the effects of TLR stimulation in cancer, expression of various TLRs in different types of tumors, and finally the role of TLRs in anti-cancer immunity and tumor rejection. Frontiers Media S.A. 2019-10-22 /pmc/articles/PMC6817561/ /pubmed/31695691 http://dx.doi.org/10.3389/fimmu.2019.02388 Text en Copyright © 2019 Urban-Wojciuk, Khan, Oyler, Fåhraeus, Marek-Trzonkowska, Nita-Lazar, Hupp and Goodlett. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Urban-Wojciuk, Zuzanna
Khan, Mohd M.
Oyler, Benjamin L.
Fåhraeus, Robin
Marek-Trzonkowska, Natalia
Nita-Lazar, Aleksandra
Hupp, Ted R.
Goodlett, David R.
The Role of TLRs in Anti-cancer Immunity and Tumor Rejection
title The Role of TLRs in Anti-cancer Immunity and Tumor Rejection
title_full The Role of TLRs in Anti-cancer Immunity and Tumor Rejection
title_fullStr The Role of TLRs in Anti-cancer Immunity and Tumor Rejection
title_full_unstemmed The Role of TLRs in Anti-cancer Immunity and Tumor Rejection
title_short The Role of TLRs in Anti-cancer Immunity and Tumor Rejection
title_sort role of tlrs in anti-cancer immunity and tumor rejection
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6817561/
https://www.ncbi.nlm.nih.gov/pubmed/31695691
http://dx.doi.org/10.3389/fimmu.2019.02388
work_keys_str_mv AT urbanwojciukzuzanna theroleoftlrsinanticancerimmunityandtumorrejection
AT khanmohdm theroleoftlrsinanticancerimmunityandtumorrejection
AT oylerbenjaminl theroleoftlrsinanticancerimmunityandtumorrejection
AT fahraeusrobin theroleoftlrsinanticancerimmunityandtumorrejection
AT marektrzonkowskanatalia theroleoftlrsinanticancerimmunityandtumorrejection
AT nitalazaraleksandra theroleoftlrsinanticancerimmunityandtumorrejection
AT hupptedr theroleoftlrsinanticancerimmunityandtumorrejection
AT goodlettdavidr theroleoftlrsinanticancerimmunityandtumorrejection
AT urbanwojciukzuzanna roleoftlrsinanticancerimmunityandtumorrejection
AT khanmohdm roleoftlrsinanticancerimmunityandtumorrejection
AT oylerbenjaminl roleoftlrsinanticancerimmunityandtumorrejection
AT fahraeusrobin roleoftlrsinanticancerimmunityandtumorrejection
AT marektrzonkowskanatalia roleoftlrsinanticancerimmunityandtumorrejection
AT nitalazaraleksandra roleoftlrsinanticancerimmunityandtumorrejection
AT hupptedr roleoftlrsinanticancerimmunityandtumorrejection
AT goodlettdavidr roleoftlrsinanticancerimmunityandtumorrejection

Ejemplares similares