Cargando…

Genome-wide association study identifies seven novel loci associating with circulating cytokines and cell adhesion molecules in Finns

BACKGROUND: Inflammatory processes contribute to the pathophysiology of multiple chronic conditions. Genetic factors play a crucial role in modulating the inflammatory load, but the exact mechanisms are incompletely understood. OBJECTIVE: To assess genetic determinants of 16 circulating cytokines an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sliz, Eeva, Kalaoja, Marita, Ahola-Olli, Ari, Raitakari, Olli, Perola, Markus, Salomaa, Veikko, Lehtimäki, Terho, Karhu, Toni, Viinamäki, Heimo, Salmi, Marko, Santalahti, Kristiina, Jalkanen, Sirpa, Jokelainen, Jari, Keinänen-Kiukaanniemi, Sirkka, Männikkö, Minna, Herzig, Karl-Heinz, Järvelin, Marjo-Riitta, Sebert, Sylvain, Kettunen, Johannes
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2019
Materias:	Complex Traits
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6817708/ https://www.ncbi.nlm.nih.gov/pubmed/31217265 http://dx.doi.org/10.1136/jmedgenet-2018-105965

Ejemplares similares

Circulating metabolites and the risk of type 2 diabetes: a prospective study of 11,896 young adults from four Finnish cohorts
por: Ahola-Olli, Ari V., et al.
Publicado: (2019)

Could vitamin D reduce obesity-associated inflammation? Observational and Mendelian randomization study
por: Palaniswamy, Saranya, et al.
Publicado: (2020)

The Role of Inflammatory Cytokines as Intermediates in the Pathway from Increased Adiposity to Disease
por: Kalaoja, Marita, et al.
Publicado: (2021)

NAFLD risk alleles in PNPLA3, TM6SF2, GCKR and LYPLAL1 show divergent metabolic effects
por: Sliz, Eeva, et al.
Publicado: (2018)

Inflammatory Diseases, Inflammatory Biomarkers, and Alzheimer Disease: An Observational Analysis and Mendelian Randomization
por: Huang, Jian, et al.
Publicado: (2023)

Longitudinal metabolomics of increasing body-mass index and waist-hip ratio reveals two dynamic patterns of obesity pandemic
por: Mäkinen, Ville-Petteri, et al.
Publicado: (2023)

Reproductive history and blood cell DNA methylation later in life: the Young Finns Study
por: Harville, Emily W., et al.
Publicado: (2021)

The interplay between inflammatory cytokines and cardiometabolic disease: bi-directional mendelian randomisation study
por: Karhunen, Ville, et al.
Publicado: (2023)

A Genome-Wide Association Study Identifies UGT1A1 as a Regulator of Serum Cell-Free DNA in Young Adults: The Cardiovascular Risk in Young Finns Study
por: Jylhävä, Juulia, et al.
Publicado: (2012)

Cross-sectionally Calculated Metabolic Aging Does Not Relate to Longitudinal Metabolic Changes—Support for Stratified Aging Models
por: Ala-Korpela, Mika, et al.
Publicado: (2023)

Does neuregulin-1 play a role in Type A behavior? The cardiovascular risk in young Finns study
por: Service, Helena M, et al.
Publicado: (2008)

Metabolic profiling of pregnancy: cross-sectional and longitudinal evidence
por: Wang, Qin, et al.
Publicado: (2016)

Vitamin D Status and Components of Metabolic Syndrome in Older Subjects from Northern Finland (Latitude 65°North)
por: Mutt, Shivaprakash Jagalur, et al.
Publicado: (2019)

Exploring Causality between TV Viewing and Weight Change in Young and Middle-Aged Adults. The Cardiovascular Risk in Young Finns Study
por: Helajärvi, Harri, et al.
Publicado: (2014)

No Association of nineteenCOX-2 gene variants to preclinical markers of atherosclerosis The Cardiovascular Risk in Young Finns Study
por: Lähteelä, Kati, et al.
Publicado: (2012)

Genome-Wide Association Study Implicates Atrial Natriuretic Peptide Rather Than B-Type Natriuretic Peptide in the Regulation of Blood Pressure in the General Population
por: Salo, Perttu P., et al.
Publicado: (2017)

Cardiometabolic Health Among Adult Offspring of Hypertensive Pregnancies: The Cardiovascular Risk in Young Finns Study
por: Tapp, Robyn J., et al.
Publicado: (2018)

Cohort Profile: 46 years of follow-up of the Northern Finland Birth Cohort 1966 (NFBC1966)
por: Nordström, Tanja, et al.
Publicado: (2021)

Subtle increases in heart size persist into adulthood in growth restricted babies: the Cardiovascular Risk in Young Finns Study
por: Arnott, Clare, et al.
Publicado: (2015)

Epigenome-450K-wide methylation signatures of active cigarette smoking: The Young Finns Study
por: Mishra, Pashupati P., et al.
Publicado: (2020)

Systematic evaluation of the association between hemoglobin levels and metabolic profile implicates beneficial effects of hypoxia
por: Auvinen, Juha, et al.
Publicado: (2021)

Metabolic profiling of angiopoietin-like protein 3 and 4 inhibition: a drug-target Mendelian randomization analysis
por: Wang, Qin, et al.
Publicado: (2020)

Potential determinants of vitamin D in Finnish adults: a cross-sectional study from the Northern Finland birth cohort 1966
por: Palaniswamy, Saranya, et al.
Publicado: (2017)

The relationship of trait-like compassion with epigenetic aging: The population-based prospective Young Finns Study
por: Dobewall, Henrik, et al.
Publicado: (2023)

Impact of Ideal Cardiovascular Health in Childhood on the Retinal Microvasculature in Midadulthood: Cardiovascular Risk in Young Finns Study
por: Campbell, Matthew D., et al.
Publicado: (2018)

Association of Physical Activity in Childhood and Early Adulthood With Carotid Artery Elasticity 21 Years Later: The Cardiovascular Risk in Young Finns Study
por: Pälve, Kristiina S., et al.
Publicado: (2014)

Childhood Dyslipidemia and Carotid Atherosclerotic Plaque in Adulthood: The Cardiovascular Risk in Young Finns Study
por: Koskinen, Juhani S., et al.
Publicado: (2023)

Prospective Relationship of Change in Ideal Cardiovascular Health Status and Arterial Stiffness: The Cardiovascular Risk in Young Finns Study
por: Aatola, Heikki, et al.
Publicado: (2014)

Insulin resistance and systemic metabolic changes in oral glucose tolerance test in 5340 individuals: an interventional study
por: Wang, Qin, et al.
Publicado: (2019)

Determinants of exercise peak arterial blood pressure, circulatory power, and exercise cardiac power in a population based sample of Finnish male and female aged 30 to 47 years: the Cardiovascular Risk in Young Finns Study
por: Hulkkonen, Janne, et al.
Publicado: (2014)

MEIS1 and BTBD9: genetic association with restless leg syndrome in end stage renal disease
por: Schormair, Barbara, et al.
Publicado: (2011)

A genome-wide association study of men with symptoms of testicular dysgenesis syndrome and its network biology interpretation
por: Dalgaard, Marlene D, et al.
Publicado: (2011)

Whole exome sequencing of familial hypercholesterolaemia patients negative for LDLR/APOB/PCSK9 mutations
por: Futema, Marta, et al.
Publicado: (2014)

Identification of a functional variant in the KIF5A-CYP27B1-METTL1-FAM119B locus associated with multiple sclerosis
por: Alcina, Antonio, et al.
Publicado: (2013)

Mapping of hepatic expression quantitative trait loci (eQTLs) in a Han Chinese population
por: Wang, Xiaoliang, et al.
Publicado: (2014)

An X chromosome-wide association analysis identifies variants in GPR174 as a risk factor for Graves’ disease
por: Chu, Xun, et al.
Publicado: (2013)

Progressive influence of body mass index-associated genetic markers in rural Gambians
por: Fulford, Anthony J, et al.
Publicado: (2015)

Haplotype-based approach to known MS-associated regions increases the amount of explained risk
por: Khankhanian, Pouya, et al.
Publicado: (2015)

The regulatory element READ1 epistatically influences reading and language, with both deleterious and protective alleles
por: Powers, Natalie R, et al.
Publicado: (2016)

A study of common Mendelian disease carriers across ageing British cohorts: meta-analyses reveal heterozygosity for alpha 1-antitrypsin deficiency increases respiratory capacity and height
por: North, Teri-Louise, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_8n2j1crd216ntffqsj1rc3d1qo