Omomyc Reveals New Mechanisms To Inhibit the MYC Oncogene

The MYC oncogene is upregulated in human cancers by translocation, amplification, and mutation of cellular pathways that regulate Myc. Myc/Max heterodimers bind to E box sequences in the promoter regions of genes and activate transcription. The MYC inhibitor Omomyc can reduce the ability of MYC to b...

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Detalles Bibliográficos
Autores principales: Demma, Mark J., Mapelli, Claudio, Sun, Angie, Bodea, Smaranda, Ruprecht, Benjamin, Javaid, Sarah, Wiswell, Derek, Muise, Eric, Chen, Shiying, Zelina, John, Orvieto, Federica, Santoprete, Alessia, Altezza, Simona, Tucci, Federica, Escandon, Enrique, Hall, Brian, Ray, Kallol, Walji, Abbas, O’Neil, Jennifer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6817756/
https://www.ncbi.nlm.nih.gov/pubmed/31501275
http://dx.doi.org/10.1128/MCB.00248-19

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