Decoupling a tandem-repeat protein: Impact of multiple loop insertions on a modular scaffold

The simple topology and modular architecture of tandem-repeat proteins such as tetratricopeptide repeats (TPRs) and ankyrin repeats makes them straightforward to dissect and redesign. Repeat-protein stability can be manipulated in a predictable way using site-specific mutations. Here we explore a di...

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Detalles Bibliográficos
Autores principales: Perez-Riba, Albert, Komives, Elizabeth, Main, Ewan R. G., Itzhaki, Laura S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6817815/
https://www.ncbi.nlm.nih.gov/pubmed/31659184
http://dx.doi.org/10.1038/s41598-019-49905-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6817815/
https://www.ncbi.nlm.nih.gov/pubmed/31659184
http://dx.doi.org/10.1038/s41598-019-49905-4

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