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Decoupling a tandem-repeat protein: Impact of multiple loop insertions on a modular scaffold
The simple topology and modular architecture of tandem-repeat proteins such as tetratricopeptide repeats (TPRs) and ankyrin repeats makes them straightforward to dissect and redesign. Repeat-protein stability can be manipulated in a predictable way using site-specific mutations. Here we explore a di...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6817815/ https://www.ncbi.nlm.nih.gov/pubmed/31659184 http://dx.doi.org/10.1038/s41598-019-49905-4 |